聚异丁烯及其热塑性弹性体:怎样从工业走向医疗  

Polyisobutylene and its thermoplastic elastomers:how to transform from industry to medical treatment

作　　者：姜力 方小娟 潘邦伦 林翰超 李伟 Jiang Li;Fang Xiaojuan;Pan Banglun;Lin Hanchao;Li Wei(Laboratory Medical School and School of Life Science,Wenzhou Medical University,Key Laboratory of Laboratory Medicine of Ministry of Education,Zhejiang Provincial Key Laboratory of Medical Genetics,Wenzhou 325035,Zhejiang Province,China)

机构地区：[1]温州医科大学检验医学院、生命科学学院,检验医学教育部重点实验室,浙江省医学遗传学重点实验室,浙江省温州市325035

出　　处：《中国组织工程研究》2020年第22期3559-3565,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家重点研发计划课题(2017YFC1104502),课题名称:人工晶状体的临床前试验,项目负责人:李伟。

摘　　要：背景:聚异丁烯嵌段共聚物及其交联产物是一类新型的热塑性弹性体,具有独特性质和优异的生物相容性,有望作为医用生物材料得到广泛应用。目的:综述聚异丁烯及其热塑性弹性体的研究进展及应用,讨论聚异丁烯类材料作为可植入医疗器材的应用前景。方法:应用计算机检索1958至2019年PubMed数据库、Web of science数据库、中国知网和万方平台收录的与聚异丁烯生物材料相关的文献。英文检索词为"polyisobutylene and block copolymer,polyisobutylene and thermoplastic elastomer,polyisobutylene and biomaterials,polyisobutylene and modification,polyisobutylene and medical application",中文检索词为"聚异丁烯,嵌段共聚物;聚异丁烯,热塑性弹性体;聚异丁烯,生物材料;聚异丁烯,修饰;聚异丁烯,医学应用",按纳入、排除标准最后共纳入文献65篇进行综述。结果与结论:聚异丁烯嵌段共聚物及其交联产物具有良好的生物相容性和稳定性。在充分利用聚异丁烯类材料自身优势的基础上,通过与不同材料的结合,利用新技术对其进行改性和修饰,未来在诸如眼科植入材料、软生物材料和药物控释载体等医用植入材料方面将展现出更强的竞争力。BACKGROUND:Polyisobutylene and block copolymer and its crosslinked product are a kind of novel thermoplastic elastomer.They have unique properties and excellent biocompatibility,which is a promising medical biomaterial and applied extensively.OBJECTIVE:To review the research progress and applications of polyisobutylene and its thermoplastic elastomers,and to discuss the application prospect of polyisobutylene-based polymers as medical implant materials.METHODS:A computer-based retrieval of Pub Med,Web of Science,CNKI and Wan Fang databases was conducted for the articles about polyisobutylene published from 1958 to 2019.The key words were"polyisobutylene and block copolymer,polyisobutylene and thermoplastic elastomer,polyisobutylene and biomaterials,polyisobutylene and modification,polyisobutylene and medical application"in English and Chinese,respectively.In accordance with the inclusion and exclusion criteria,65 eligible articles were included for review.RESULTS AND CONCLUSION:Polyisobutylene and block copolymer and its crosslinked products have favorable biocompatibility and stability.By making full use of polyisobutylene-based materials’advantages,with the combination of other biomaterials and usage of new technology for surface modification,the copolymer will be more competitive in the field of medical implant in the future,including eye implant materials,soft biomaterials and drug delivery systems.

关 键 词：聚异丁烯 嵌段共聚物 交联聚异丁烯 表面改性 生物医用材料 热塑性弹性体 生物材料 医学应用 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]