3193例手足口病病原学特征分析  

Analysis of the etiological characteristics of hand-foot-mouth disease in 3193 cases

作　　者：付金玲[1] 李其林 曹玉忠[1] 余勋[1] FU Jin-ling;LI Qi-lin;CAO Yu-zhong;YU Xun(MCH Hospital of Dongguan City,Dongguan 523000,China;Guangzhou Red Cross Hospital,Guangzhou 510220,China)

机构地区：[1]东莞市妇幼保健院,广东东莞523000 [2]广州市红十字会医院,广东广州510220

出　　处：《皮肤性病诊疗学杂志》2020年第1期23-25,共3页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的:分析本地区手足口病的病原学构成及流行病学特征,为其综合防治提供依据。方法:收集2015-2018年本院皮肤科及手足口病专科送检的手足口病患者粪便、肛拭标本,采用Real-Time PCR技术进行柯萨奇病毒A组16型(CA16)、肠道病毒71型(EV71)及肠道病毒通用型(enteroviruses,EV)检测。结果:共收集手足口病病例3193例,其中2073例(64.92%)肠道病毒检测阳性,其中CA16和EV71分别占8.44%和8.25%。发病人群主要集中在5岁以下儿童(97.41%),其中1~2岁儿童占45.78%。男童感染EV71型阳性率高于女童(χ^2=4.49,P=0.034)。结论:2015-2018年东莞市手足口病发病流行优势株为CA16和EV71以外的其他EV,提示今后手足口病监测工作应加强对EV71和CA16以外的其他肠道病毒的分型检测;手足口病发病年龄以5岁以下居多,男童感染EV71型病毒机率要大于女童,应加强该年龄段的管理及防护。Objective:To analyze the etiological and epidemic features of hand-foot-mouth disease(HFMD)in Dongguan from 2015 to 2018,providing basic information for disease prevention and control.Methods:Real-time fluorescent quantitative PCR was used for detecting the nucleic acid of coxsackievirus A16(CA16),enterovirus 71(EV71)and universal enteroviruses(EV)in anal swab samples from suspected HFMD patients.Results:Out of 3193 HFMD specimens,2073 samples(64.92%)were enterovirus nucleic acid positive.The positive rates of CA16 and EV71 were 8.44%and 8.25%,respectively.Majority of patients(97.41%)with HFMD were age<5 years old.Patients aged 1-2 years accounted for 45.78%.The positive rate of EV71 infection in boys was higher than that in girls(χ^2=4.49,P=0.034).Conclusions:The main pathogens of HFMD were EVs other than CA16 and EV71 from year 2015-2018 in DongGuan,suggesting that EVs detection is necessary in monitoring HFMD.Because that there is a high prevalence in children under 5 years of age,and that boys are more likely to be infected with EV71 than girls,the management and protection of children in this age group should be strengthened in the management of HFMD.

关 键 词：手足口病 柯萨奇病毒A16 肠道病毒71 

分 类 号：R725.1[医药卫生—儿科]