血清白蛋白、γ球蛋白在儿童风湿性疾病与细菌或病毒感染性疾病发热中的鉴别诊断价值  

The differential diagnostic value of serum albumin,γglobulin in fever of children with rheumatic diseases,bacteria or virus infectious diseases

作　　者：张在亭 王涛 范春燕 王玲玲 余婧 ZHANG Zaiting;WANG Tao;FAN Chunyan(Department of Pediatrics,The First Hospital of Zibo City,Shandong,Zibo 255200,China)

机构地区：[1]山东省淄博市第一医院儿科,255200

出　　处：《河北医药》2020年第5期681-684,689,共5页Hebei Medical Journal

摘　　要：目的探讨儿童发热患者早期血清白蛋白、γ球蛋白、β球蛋白、α1球蛋白及α2球蛋白水平与发热病因的相关性。方法收集2013年1月至2017年12月风湿疾病52例、细菌感染76例与病毒感染99例,3组发热患儿早期血清蛋白电泳结果,回顾分析风湿疾病组与细菌感染组或病毒感染组的血清白蛋白、γ球蛋白、β球蛋白、α1球蛋白及α2球蛋白水平及异常率。结果风湿疾病组患儿白蛋白水平明显低于细菌感染组和病毒感染组,白蛋白降低率明显高于细菌感染组和病毒感染组(P<0.05)。风湿疾病组患儿γ球蛋白水平及升高率明显高于细菌感染组和病毒感染组(P<0.05)。结论白蛋白水平降低、γ球蛋白水平升高提示非感染性发热风湿性疾病可能性大;反之,提示感染性发热细菌或病毒感染可能性大。Objective To investigate the correlation between the serum levels of albumin,γglobulin,βglobulin,α1 globulin,α2 globulin and fever cause in children with rheumatic diseases,bacteria or virus infectious diseases.Methods A total of 52 children patients with rheumatic diseases were enrolled as rheumatic disease group,and 76 patients with bacterial infection were enrolled as bacteria infection group,and 99 patients with viral infection were enrolled as virus infection group,who were treated in our hospital from January 2013 to December 2017.The serum levels of albumin,γglobulin,βglobulin,α1 globulin andα2 globulin were detected by protein electrophoresis,and the examination results were observed and compared among the three groups.Results The albumin levels in rheumatic disease group were significantly lower than those in bacteria infection group and virus infection group(P<0.05).The decrease rate of albumin in rheumatic diseases group was significantly higher than that in bacteria infection group and in virus infection group(P<0.05).Moreover the levels of and the increase rate ofγglobulin in rheumatic disease group were significantly higher than those in bacteria infection group and virus infection group(P<0.05).Conclusion The decrease of albumin levels and increase ofγglobulin levels suggest that the children patients may suffer from rheumatic disease with non-infectious fever.On the contrary,increase of albumin levels and decrease ofγglobulin levels suggest that the children patients may suffer from rheumatic disease with infectious fever caused by bacteria or virus.

关 键 词：血清白蛋白 Γ球蛋白 儿童 发热 

分 类 号：R441.3[医药卫生—诊断学]