噬菌体疗法及其在美洲幼虫腐臭病中的研究进展  

Advances in Phage Therapy and Its Application in American Foulbrood disease(Paenibacillus larvae)

作　　者：董志祥 罗智文 张棋麟 郭军[1] DONG Zhi-xiang;LUO Zhi-wen;ZHANG Qi-lin;GUO Jun(Coll.of Life Sci.,Kunming Uni.of Sci.&Technol.,Kunming 650500)

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500

出　　处：《微生物学杂志》2020年第1期109-116,共8页Journal of Microbiology

基　　金：国家自然科学基金项目(31660695)。

摘　　要：美洲幼虫腐臭病是西方蜜蜂中最严重的细菌病之一,给养蜂业带来了严重的损失。幼虫芽胞杆菌是幼蜂感染美洲幼虫腐臭病的病原菌。由于抗生素产生的耐药性越来越严重,并且抗生素的使用会破坏宿主肠道菌群,使蜂群处于高危的环境中,因此迫切需要抗生素治疗的替代技术,而噬菌体在预防和控制细菌耐药性方面已显示出显著的优势。主要综述了噬菌体疗法、安全性及其在蜜蜂美洲幼虫腐臭病中的研究现状,介绍了噬菌体疗法在各类细菌病中的研究与应用,对今后噬菌体治疗蜜蜂细菌病研究方向进行了展望。American foulbrood disease is one of the most serious bacterial diseases among the Apis mellifera,causing severe economic losses to beekeepers.Paenibacillus larvae is a pathogenic bacterium that infects larvae from American foulbrood disease.As antibiotic resistance grows more and more severe,and the antibiotic application destroys host gut community,putting colonies in high-risk environments,therefore,an alternative technology to antibiotic treatment are urgently needed.Phages have shown significant advantages in preventing and controlling bacterial resistance.This paper reviews mainly phage therapy and safety and the research status of phage in American foulbrood disease and the research and application of phage therapy in various bacterial diseases.Finally,the future research direction of phage therapy for bee bacterial disease is prospected.

关 键 词：美洲幼虫腐臭病 耐药性 噬菌体 噬菌体鸡尾酒 裂解活性 幼虫芽胞杆菌 

分 类 号：Q939.48[生物学—微生物学]