醋酸碘苯促进的氧化反应在构建2-氨基-1,3,4-噻二唑分子中的应用  

Application of Iodobenzene Acetate Promoted Oxidation in the Synthesis of 2-Amino-1,3,4-thiadiazole Molecules

作　　者：陆雨函 韩颖芝 孙亚栋[1] 阿布力米提·阿布都卡德尔[1] 王多志[1] 刘晨江[1] Lu Yuhan;Han Yingzhi;Sun Yadong;Abdukader Ablimit;Wang Duozhi;Liu Chenjiang(College of Chemistry and Chemical Engineering,Xinjiang University,Urumqi 830046)

机构地区：[1]新疆大学化学与化工学院,乌鲁木齐830046

出　　处：《有机化学》2020年第2期447-453,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21662032,21562039);新疆大学博士科研启动基金(No.BS150225)资助项目.

摘　　要：报道了一种用高价碘试剂促进缩氨基硫脲分子内氧化偶联反应,能够有效地合成2-氨基-1,3,4-噻二唑类衍生物.高价碘可以作为温和的反应试剂,拥有毒性低、廉价可循环易操作的特性.该反应具有原料易制得、操作简便以及较好的底物适用性等特点.反应机理也进行了初步研究.A highly method for intramolecular oxidative coupling reaction of thiosemicarbazone promoted by hypervalent iodine reagent was reported. 2-Amino-1,3,4-thiadiazole derivatives could be synthesized effectively. Hypervalent iodine could be used as a mild reagent with low toxicity, low cost, easy circulation and operation. The reaction had the advantages of easy preparation of raw materials, simple operation and better performance. The applicability of substrates and the reaction mechanism were also preliminarily studied.

关 键 词：高价碘 氧化 芳香醛 噻二唑 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]