PDGF、HMGB1在子宫内膜异位症患者血清中的表达及其临床意义  

Expression and Clinical Significance of PDGF and HMGB1 in Serum of Patients with Endo netriosis

作　　者：张达 袁芳[2] 杜艳辉 罗友军[2] 吕映频[2] 林伟[2] 牛兆园[2] ZHANG Da;YUAN Fang;DU Yan-hui(Qingdao University,Qingdao Shandong,266000)

机构地区：[1]青岛大学,山东青岛266000 [2]青岛大学附属医院,山东青岛266071

出　　处：《医学临床研究》2020年第3期412-414,418,共4页Journal of Clinical Research

摘　　要：【目的】探讨血小板衍生生长因子(PDGF)、高迁移率族蛋白B1(HMGB1)在子宫内膜异位症(EMs)患者血清的表达及其临床意义。【方法】选取本院2016年3月至2019年3月EMs患者80例设为观察组,纳入同期健康体检女性68例为对照组。检测并比较两组血清中PDGF、HMGB1的表达,并分析其与EMs患者临床分期、有无淋巴结转移、有无深部浸润病灶的相关性,logistic回归分析EMs发病的影响因素。【结果】观察组血清PDGF、HMGB1水平显著高于对照组(P<0.05);临床分期Ⅲ~Ⅳ期、有淋巴结转移、有深部浸润病灶EMs患者血清PDGF、HMGB1水平高于临床分期为Ⅰ~Ⅱ期、无淋巴结转移、无深部浸润病灶患者(P<0.05);logistic回归分析显示:血清PDGF、HMGB1均为EMs发病的危险因素(P<0.05);经Spearman相关分析显示:血清PDGF、HMGB1表达与EMs患者Ⅲ~Ⅳ期、淋巴结转移和深部浸润病灶呈正相关(均P<0.05)。【结论】EMs患者.血清PDGF、HMGB1呈异常高表达,且与Ⅲ~Ⅳ期、淋巴结转移和深部浸润病灶密切相关,可为本病病情监测及预后评估提供依据,可为后续治疗提供新靶点。【Objective】To investigate the expression of platelet-derived growth factor(PDGF)and high mobility group protein B1(HMGB1)in the serum of patients with endometriosis(EM s)and its clinical significance.【Methods】From March 2016 to March 2019,80 EMS patients in our hospital were selected as the observation group and 68 healthy women were included as the control group.The expression of PDGF and HMGB1 in serum of the two groups were detected and compared,and the correlation between PDGF and HMGB1 and clinical stage,lymph node metastasis and deep infiltration of EMS patients were analyzed.The influencing factors of EMs were analyzed by logistic regression.【Results】The levels of PDGF and HMGB1 in the observation group were significantly higher than those in the control group(P<0.05);the serum levels of PDGF and HMGB1 in EMs patients with clinical stage Ⅲ~Ⅳ,lymph node metastasis and deep infiltrating focus were higher than those in patients with clinical stage Ⅰ~Ⅱ,no lymph node metastasis and no deep infiltrating focus(P<0.05);Logistic regression analysis showed that serum PDGF and HMGB1 were risk factors of EMs(P<0.05);the results of Spearman correlation analysis showed that the expression of PDGF and HMGB1 in serum was positively correlated with stage Ⅲ~Ⅳ,lymph node metastasis and deep infiltrating lesions in EMs patients(all P<0.05).【Conclusion】The serum PDGF and HMGB1 of patients with EMs are abnormally high expression,which are closely related to stage Ⅲ~Ⅳ,lymph node metastasis and deep infiltrative lesions.It can provide basis for disease monitoring and prognosis evaluation,and provide new targets for follow-up treatment.

关 键 词：子宫内膜异位症 血小板源生长因子 

分 类 号：R711.71[医药卫生—妇产科学]