Neutron-activated biodegradable samarium-153 acetylacetonate-poly-L-lactic acid microspheres for intraarterial radioembolization of hepatic tumors  

作　　者：Yin-How Wong Hun-Yee Tan Azahari Kasbollah Basri Johan Jeet Abdullah Rajendra Udyavara Acharya Chai-Hong Yeong 

机构地区：[1]School of Medicine,Faculty of Health and Medical Sciences,Taylor’s University,Subang Jaya 47500,Selangor,Malaysia [2]School of Biosciences,Faculty of Health and Medical Sciences,Taylor’s University,Subang Jaya 47500,Selangor,Malaysia [3]Medical Technology Division,Malaysian Nuclear Agency,Bangi 43000,Selangor,Malaysia [4]Department of Electronics and Computer Engineering,Ngee Ann Polytechnic,Singapore 599489,Singapore

出　　处：《World Journal of Experimental Medicine》2020年第2期10-25,共16页世界实验医学杂志

基　　金：Supported by Fundamental Research Grant Scheme sanctioned by the Ministry of Education,Malaysia,No.FRGS/1/2019/SKK06/TAYLOR/02/3。

摘　　要：BACKGROUND Liver cancer is the 6 th most common cancer in the world and the 4 th most common death from cancer worldwide.Hepatic radioembolization is a minimally invasive treatment involving intraarterial administration of radioembolic microspheres.AIM To develop a neutron-activated,biodegradable and theranostics samarium-153 acetylacetonate(153SmAcAc)-poly-L-lactic acid(PLLA)microsphere for intraarterial radioembolization of hepatic tumors.METHODS Microspheres with different concentrations of 152SmAcAc(i.e.,100%,150%,175%and 200%w/w)were prepared by solvent evaporation method.The microspheres were then activated using a nuclear reactor in a neutron flux of 2×10^12n/cm^2/s^1,converting 152Sm to Samarium-153(153)Sm)via 152Sm(n,γ) 153Sm reaction.The SmAcAc-PLLA microspheres before and after neutron activation were characterized using scanning electron microscope,energy dispersive X-ray spectroscopy,particle size analysis,Fourier transform infrared spectroscopy,thermo-gravimetric analysis and gamma spectroscopy.The in-vitro radiolabeling efficiency was also tested in both 0.9% sodium chloride solution and human blood plasma over a duration of 550 h.RESULTS The SmAcAc-PLLA microspheres with different SmAcAc contents remained spherical before and after neutron activation.The mean diameter of the microspheres was about 35μm.Specific activity achieved for 153SmAcAc-PLLA microspheres with 100%,150%,175%and 200%(w/w)SmAcAc after 3 h neutron activation were 1.7±0.05,2.5±0.05,2.7±0.07,and 2.8±0.09 GBq/g,respectively.The activity of per microspheres were determined as 48.36±1.33,74.10±1.65,97.87±2.48,and 109.83±3.71 Bq for 153SmAcAc-PLLA microspheres with 100%,150%,175%and 200%(w/w)SmAcAc.The energy dispersive X-ray and gamma spectrometry showed that no elemental and radioactive impurities present in the microspheres after neutron activation.Retention efficiency of 153Sm in the SmAcAc-PLLA microspheres was excellent(approximately 99%)in both 0.9%sodium chloride solution and human blood plasma over a duration of 55

关 键 词：RADIOEMBOLIZATION Samarium-153 Yittrium-90 BIODEGRADABLE microsphere Liver tumors NEUTRON activation 

分 类 号：O57[理学—粒子物理与原子核物理]