人类血小板抗体在不同年龄性别儿童免疫性血小板减少症中的表达及其治疗中的意义  

Expression of human platelet antibody in different age and gender children with immune thrombocytopenia and its therapeutic significance

作　　者：张刘仟 朱从奎[1] 尤建国[1] 顾小文 Zhang Liuqian;Zhu Congkui;You Jianguo;Gu Xiaowen(Affiliated Huai′an No.1 Hospital of Nanjing Medical University,Huai′an 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院,江苏淮安223300

出　　处：《海军医学杂志》2020年第2期155-158,共4页Journal of Navy Medicine

摘　　要：目的 研究人类血小板抗体(human platelet antibody,HPA)在不同年龄段儿童免疫性血小板减少症(immune thrombocytopenia,ITP)中的表达及其治疗中的意义。方法 选取南京医科大学附属淮安第一医院2019年1-8月60例原发性ITP并行HPA检测的患者作为研究对象,根据年龄的不同分为<3岁组和≥3岁组(不超过18岁),根据HPA值的不同分为1∶10组、<1∶10组和>1∶10组。分析HPA和年龄、性别及治疗的短期有效率之间的关系。结果 HPA检测患者中不同年龄阶段的性别比例明显不同(P<0.05),<3岁组男性占多数,≥3岁组女性占多数。不同性别HPA阳性率比较,男童和女童比较HPA阳性率比较差异无统计学意义(P>0.05)。<3岁组HPA阳性率高于≥3岁组(P<0.05)。HPA<1∶10组、1∶10组和> 1∶10组ITP患者短期有效率分别为90.00%、90.90%和100.00%。HPA>1∶10组短期有效率高于HPA<1∶10组和1∶10组(P<0. 05)。但HPA<1∶10组和1∶10组ITP患者短期有效率比较差异无统计学意义(P>0.05)。结论 ITP患者<3岁组男性占多数,其HPA阳性率更高。同时HPA检测在一定程度上能指导ITP诊断,HPA>1∶10组在临床上短期有效率更高。Objective To investigate the expression of human platelet antibody(HPA)among children with immune throm?bocytopenia(ITP)at different age stages and its therapeutic significance.Methods Sixty patients with primary ITP and HPA detec?tion admitted into the hospital for treatment from January to August 2019 were recruited as research subjects.The patients were divided into groups in accordance with different ages,i.e.the<3 years old group and the≥3 years old group,and by different HPA values,they were subdivided into the 1∶10 group,the<1∶10 group and the>1∶10 group.The relationship between HPA and age,gender,and short?term efficacy was analyzed in the study.Results The sex ratios of HPA patients at different ages were significantly different(P<0.05).In the<3 years old group,males constituted the majority,while in the≥3 years old group(not older than 18)females constituted the majority.There was no statistical significance in HPA positive rates,when comparisons were made between boys and girls(P>0.05).HPA positive rate in the<3 years old group was higher than that in the≥3 years old group(P<0.05).The short?term effective rates of the ITP patients in the HPA<1∶10 group,the 1∶10 group and the>1∶10 group were 90.00%,90.90%and 100.00%respectively.The short?term effective rate of the HPA>1∶10 group was higher than those of the HPA<1∶10 group and the 1∶10 group(P<0.05).However,no statistical significance could be seen in the short?term effective rate,when comparisons were made between the HPA<1∶10 group and the ITP group(P>0.05).Conclusion Male patients in the<3 years old ITP group consti?tuted the majority,with higher positive rate of HPA.To a certain extent,HPA detection could be served as a direction for ITP diagno?sis,and the short?term clinical efficacy of the HPA>1∶10 group seemed to be higher.

关 键 词：人类血小板抗体 年龄 儿童免疫性血小板减少症 

分 类 号：R558.2[医药卫生—血液循环系统疾病]