碱金属盐催化1,2,4-三唑与α,β-不饱和酮及二酰亚胺的氮杂Michael反应  

Alkali Salt-Catalyzed Aza-Michael Addition of 1,2,4-Triazole to α,β-Unsaturated Ketones and Imides

作　　者：马奔[1] 王刚刚 周红艳[1,2] 杨靖亚[1] Ma Ben;Wang Ganggang;Zhou Hongyan;Yang Jing(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070;College of Science,Gansu Agricultural University,Lanzhou 730070)

机构地区：[1]西北师范大学化学化工学院,兰州730070 [2]甘肃农业大学理学院,兰州730070

出　　处：《有机化学》2020年第1期115-124,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21362034)资助项目。

摘　　要：发展了一种高效的碱金属盐催化1,2,4-三唑与α,β-不饱和酮及α,β-不饱和二酰亚胺的氮杂Michael加成反应的新方法,以中等到优异的产率得到目标产物.该方法原料易得,底物普适性好,反应条件温和,易实现克级规模的制备.产物容易转化为相应的γ-氨基醇.An alkali salt-catalyzed highly efficient aza-Michael addition of 1,2,4-triazole to α,β-unsaturated ketones and imides has been developed, giving the desired products in moderate to excellent yields. The salient features of this reaction involve readily available starting materials, good substrate scope, mild condition, high efficiency and ease of scale-up. The product can be transformed into corresponding γ-aminoalcohol.

关 键 词：合成方法 MICHAEL加成 烯酮 α β-不饱和二酰亚胺 含氮杂环 1 2 4-三唑 

分 类 号：O621.251[理学—有机化学]