脊髓型颈椎病动物模型制作的关注热点  

Hot spots of animal models of cervical spondylotic myelopathy

作　　者：陈盛 刘建航 刘本涛 张兆剑 李本澈 张帆 李东飞 Chen Sheng;Liu Jianhang;Liu Bentao;Zhang Zhaojian;Li Benche;Zhang Fan;Li Dongfei(Guangxi University of Chinese Medicine,Nanning 530001,Guangxi Zhuang Autonomous Region,China;Department of Bone Traumatology,Beihai Hospital of Chinese Medicine(Beihai Hospital Affiliated to Guangxi University of Chinese Medicine),Beihai 536000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学,广西壮族自治区南宁市530001 [2]北海市中医医院(广西中医药大学附属北海医院)骨伤科,广西壮族自治区北海市536000

出　　处：《中国组织工程研究》2020年第24期3890-3896,共7页Chinese Journal of Tissue Engineering Research

基　　金：广西医疗卫生适宜技术开发与推广应用项目(S2017054),项目负责人:刘建航;广西青年智库研究会(GXQNZKA-1702),项目负责人:刘建航;2010年度广西中医学院附属瑞康医院(RKZ201012),项目负责人:刘建航;广西中医药民族医药自筹科研课题(GZZC15-82),项目负责人:刘建航;中药壮瑶药制剂提升工程项目(GZZJ16-08),项目负责人:刘建航;广西教育科学“十二五”规划2015年度课题(2015B086),项目负责人:刘建航。

摘　　要：背景:脊髓型颈椎病是颈椎病中最为严重的一种发病类型,而目前其组织病理学研究仍不十分明确,主要原因在于缺乏理想的动物模型。目的:通过查阅文献回顾脊髓型颈椎病模型常用的制作方法,并对模型的不同制作进行分析评价,以促进脊髓型颈椎病动物模型的改进和完善。方法:通过下列检索词:脊髓型颈椎病、颈脊髓压迫、动物模型,cervical spondylotic myelopathy、cervical spinal compression、animal model,由第一作者检索中国知网、万方、维普、Pub Med、Medline、Embase数据库收录的从2000至2019年与脊髓型颈椎病动物模型制作相关的中、英文献,并筛选出来进行分析评价。结果与结论:①当前脊髓型颈椎病动物模型的制作方法较多,大致可分为动态造模法和静态造模法两类,且各自优缺点并存;②拧入螺钉压迫法最为常见,具有可控性强、造模周期短的优点,但对于造模动物的颈髓损害较重且致死率高;而膨胀材料压迫法科技要求难度大,但成功率高、可靠性强,有待继续完善和推广;③文章结果证实,目前脊髓型颈椎病动物模型的各种制作方法仍存在着明显的不足,还需在先前学者造模的基础上不断完善,从而实现再现性好、可重复、可分级的动物模型,以便今后在临床上为脊髓型颈椎病的治疗提供更好的理论依据。BACKGROUND:Cervical spondylotic myelopathy is one of the most serious types of cervical spondylosis.The histopathological study of cervical spondylotic myelopathy is not very clear,mainly because of the lack of ideal animal models.OBJECTIVE:To review the common methods of making cervical spondylotic myelopathy model,and analyze and evaluate the different methods of making the model,so as to promote the improvement and perfection of cervical spondylotic myelopathy animal models in the future.METHODS:The“cervical spondylotic myelopathy,cervical spinal compression,animal model”in Chinese and English,respectively were used as keywords.The first author retrieved the literature concerning construction methods of cervical spondylotic myelopathy animal model in CNKI,Wanfang,VIP,PubMed,Medline and Embase databases from 2000 to 2019,and all data were filtered for analysis and evaluation.RESULTS AND CONCLUSION:(1)There are many construction methods of cervical spondylotic myelopathy animal model at present,which can be divided into two types:dynamic modeling methods and static modeling methods,and their advantages and disadvantages coexist.(2)Screw compression is the most common construction method of cervical spondylotic myelopathy animal models,which has the advantages of strong controllability and short modeling cycle,but the damage to cervical spinal cord of animals is more serious and has a high fatality rate.The technology of expansion material compression method is difficult,but it has a high success rate and high reliability.It needs to be further improved and promoted.(3)At present,the construction methods of cervical spondylotic myelopathy animal model still have many disadvantages,and need to be improved on the basis of previous modeling by researchers,so as to realize good reproducibility,repeatable and scalable animal model making and provide a better clinical theoretical basis for cervical spondylotic myelopathy in the future.

关 键 词：脊髓型颈椎病 颈脊髓压迫 实验动物 动物模型 造模 拧入螺钉 膨胀材料 研究进展 评价 

分 类 号：R459.9[医药卫生—治疗学] R651[医药卫生—临床医学]