比较孟鲁司特钠与富马酸酮替芬治疗小儿哮喘的效果  

Comparison of the Effect of Montelukast Sodium and Ketotifen Fumarate in the Treatment of Asthma in Children

作　　者：胡巧丽 Hu Qiaoli(Nanzhao County Maternal and Child Health Hospital,Henan Province,Nanyang 474650)

机构地区：[1]河南省南召县妇幼保健院,南阳474650

出　　处：《数理医药学杂志》2020年第4期584-585,共2页Journal of Mathematical Medicine

摘　　要：目的:探讨孟鲁司特钠与富马酸酮替芬治疗小儿哮喘的效果。方法:选取2017年9月~2018年10月收治的102例小儿哮喘患儿,采用随机数字表法均分为观察组和对照组各51例。观察组采取孟鲁司特钠治疗,对照组采用富马酸酮替芬进行治疗,观察两组102例患儿症状消失时间等相关指标。结果:观察组51例患儿TNF-α、IL-2等表达水平、用力肺活量等指标、住院时间以及哮鸣音消失时间等指标明显优于对照组,对比差异显著有统计学意义(P<0.05)。结论:与富马酸酮替相比,孟鲁司特钠治疗小儿哮喘可更加有效的改善呼吸功能,有利于抑制炎症因子表达,值得临床推广。Objective:To investigate the effect of montelukast sodium and ketotifen fumarate in the treatment of asthma in children.Methods:102 children with asthma in a hospital from September 2017 to October 2018 were enrolled and divided into two groups according to the random table method.and 51 patients in the observation group were treated with montelukast sodium.In the control group,51 patients were treated with ketotifen fumarate.In the observation group,51 children were treated with montelukast sodium,while in the control group,51 children were treated with ketotifen fumarate.The time of symptom disappearance of 102 children in the two groups was observed.Results:In the observation group,TNF-α,IL-2 and other expression level,forced vital capacity,hospitalization time,wheezing sound disappearing time and other indicators significantly better than the control group,the difference was statistically significant(P<0.05).Conclusion:Compared with keto fumarate,montelukast sodium can improve respiratory function more significantly,and is benefit of inhibiting the expression of inflammatory factors.It is worthy of clinical promotion.

关 键 词：孟鲁司特钠 小儿哮喘 用力肺活量 

分 类 号：R725.6[医药卫生—儿科]