Depression and myocardial injury in ST-segment elevation myocardial infarction:A cardiac magnetic resonance imaging study  

作　　者：Zhao-Qing Sun Tong-Tong Yu Yue Ma Quan-Mei Ma Yun-Di Jiao Dong-Xu He Jia-KeWu Zong-Yu Wen Xiao-Nan Wang Yang Hou Zhi-Jun Sun 

机构地区：[1]Department of Cardiology,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning Province,China [2]Department of Radiology,Shenyang 110004,Liaoning Province,China

出　　处：《World Journal of Clinical Cases》2020年第7期1232-1240,共9页世界临床病例杂志

基　　金：the National Key R&D Program of China,No.2018YFC1311600;the Ethics Committee of the Shengjing Hospital of China Medical University Research Ethics Committee(No.2016PS373K).

摘　　要：BACKGROUND Depression is common in patients with myocardial infarction and has been independently associated with adverse outcomes.However,the association between depression and myocardial injury on cardiac magnetic resonance(CMR)in patients with ST-segment elevation myocardial infarction(STEMI)has still not been assessed.AIM To assess the association between depression and myocardial injury on CMR in patients with STEMI.METHODS A total of 107 STEMI patients undergoing primary percutaneous coronary intervention(P-PCI)were analyzed in this prospectivecohort study.Each subject completed the Patient Health Questionnaire-9(PHQ-9)to assess the presence and severity of depressive symptoms.CMR was performed at a median of 3 d after PPCI for quantifying post-MI myocardial injury.Correlations between depression identified by the PHQ-9 and myocardial injury measured on CMR were assessed.RESULTS In this study,19 patients(17.8%)were diagnosed with major depression identified by the PHQ-9≥10.PHQ-9 was analyzed both as a continuous variable and dichotomous variable.After multivariable adjustment,the proportion of patients with large infarction size was significantly higher in the major depression group(PHQ-9≥10)(OR:4.840,95%CI:1.122–20.868,P=0.034).When the PHQ-9 was evaluated as a continuous variable,after multivariable adjustment,an increased PHQ-9 score was associated with an increased risk of large infarction size(OR:1.226,95%CI:1.073–1.401,P=0.003).CONCLUSION In patients with STEMI undergoing PCI,depression was independently associated with a large infarction size.

关 键 词：DEPRESSION Patient Health Questionnaire-9 MYOCARDIAL injury ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION Cardiac magnetic resonance 

分 类 号：R542.22[医药卫生—心血管疾病] R445.2[医药卫生—内科学]