抗类风湿性关节炎滑膜增生和滑膜血管新生中药的研究进展  

Research Progress of Anti-Rheumatoid Arthritis Synovial Hyperplasia and Synovial Angiogenesis Traditional Chinese Medicine

作　　者：赵艳红[1] 金晨 周彩虹[1] 程玉瑶 陈康 张凌[1] ZHAO Yan-hong;JIN Chen;ZHOU Cai-hong;CHENG Yu-yao;CHEN Kang;ZHANG Ling(The College of Pharmacy of Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,南昌330004 [2]江西中医药大学现代中药制剂教育部重点实验室,南昌330004

出　　处：《江西中医药大学学报》2020年第2期113-116,共4页Journal of Jiangxi University of Chinese Medicine

基　　金：国家自然科学基金项目(81460595);江西省教育厅科技计划重点项目(170699)。

摘　　要：类风湿性关节炎(RA)是一种病因复杂、病理表现以滑膜炎症、关节积液、骨侵蚀和滑膜血管异常增生形成血管翳为特征的慢性进行性自身免疫系统疾病,是世界性的难治病,受到各研究领域的广泛重视。中药复方或单体成分通过干预RA对滑膜组织的异常增殖、血管新生、关节软骨和免疫系统等方面的研究取得了一定进展,研究水平已达到分子水平。笔者就中药复方和单体成分在治疗实验性RA滑膜增生和滑膜血管新生作用的研究报道进行综述,为今后研究抗RA药物提供一定参考。Rheumatoid arthritis(RA)is a kind of chronic progressive autoimmune system disease characterized by complex etiology and pathological manifestations of synovial inflammation,joint effusion,bone erosion and abnormal proliferation of synovial vasculature,which is difficult in treatment in the world and has received extensive attention in various research fields.Compound or monomer componentsin Traditional Chinese Medicine has made some progress in the study of interventionof abnormal proliferation,angiogenesis,articular cartilage and immune system of synovial tissue caused by RA,and the research has reached the molecular level.The author of this paper reviewed the research reports on the effects of compound and monomer components of traditional Chinese medicine on the treatment of experimental RA synovial hyperplasia and synovial angiogenesis,and which will provide a reference for future development on anti-RA drugs.

关 键 词：类风湿性关节炎 滑膜增生 滑膜血管新生 中药复方 中药单体成分 综述 

分 类 号：R255.6[医药卫生—中医内科学] R285.5[医药卫生—中医学]