陷窝蛋白-1与干细胞衰老、自我更新的研究进展  

Advances in Research on Caveolin-1 and Stem Cell Senescence and Self-Renewal

作　　者：孙月彤 张炳强[2] 邹伟[1,3] SUN Yue-Tong;ZHANG Bing-Qiang;ZOU Wei(College of Life Sciences,Liaoning Normal University,Dalian 116081;Key Laboratory of Cell Transplantation,Ministry of Health,Qingdao 266000;Liaoning Key Laboratory of Biotechnology and Molecular Drug Research and Development,Dalian 116081,China)

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116081 [2]卫生部细胞移植重点实验室临床中心,山东青岛266000 [3]辽宁省生物技术与分子药物研发重点实验室,辽宁大连116081

出　　处：《生物技术通讯》2020年第1期88-92,共5页Letters in Biotechnology

基　　金：国家自然科学基金(81802819)。

摘　　要：近年来有关干细胞临床应用的研究十分广泛,干细胞移植治疗各类疾病也已取得可观的效果。但随着干细胞技术的快速发展,干细胞体外增殖导致的衰老也成为制约干细胞应用的一大难题。陷窝蛋白-1是细胞膜上的一种整合膜蛋白,是形成陷窝的主要膜内在蛋白。已有研究表明,陷窝蛋白-1在细胞衰老及自我更新调节中起重要的调控作用。本文简要综述了干细胞的自我更新和衰老机制及陷窝蛋白-1的促增殖及抗衰老作用,旨在为干细胞临床应用及干细胞组织工程研究提供理论依据。In recent years,research on the clinical application of stem cells has been extensive,and stem cell transplantation has also achieved considerable effects in treating various diseases.However,with the rapid develop ment of stem cell technology,the aging caused by the proliferation of stem cells in vitro has become a major prob lem that restricts the application of stem cells.Caveolin-1 is an integral membrane protein on the cell membrane,which is the main membrane intrinsic protein that forms caveolae.It has been shown that caveolin-1 plays an im portant regulatory role in cell senescence and self-renewal regulation.This article briefly reviewed the self-renewal and aging mechanisms of stem cells and the proliferative and anti-aging effects of caveolin-1.The aim is to pro vide a theoretical basis for stem cell clinical application and stem cell tissue engineering research.

关 键 词：干细胞 细胞衰老 陷窝蛋白-1 

分 类 号：Q25[生物学—细胞生物学]