血栓弹力图检测AA途径及ADP途径血小板抑制率的回顾性分析  

A Retrospective Analysis of Platelet Inhibition Rate in AA and ADP Pathways Detected by Thrombus Elastography

作　　者：杨劲[1] 何安华[1] 李凌波 李尊严[3] YANG Jin;HE An-hua;LI Ling-bo(Hefei Second People's Hospital,Anhui 230011)

机构地区：[1]合肥市第二人民医院,230011 [2]长春博讯生物技术有限责任公司研发部 [3]北华大学附属医院输血科

出　　处：《临床输血与检验》2020年第2期118-121,共4页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：合肥市第二人民医院院级光华基金(No.201519)资助。

摘　　要：目的 回顾分析AA(花生四烯酸)抑制率和ADP(二磷酸腺苷)抑制率的影响因素及服用不同抗血小板药物的疗效。方法 选取本院从2015年3月~2018年12月检测血小板抑制率的患者114例作为分析对象,首先按AA抑制率和ADP抑制率分组,分析与其检验结果的相关性,再按照服用不同抗血小板药物分组对比分析抑制率的变化及抑制疗效。结果 患者ADP抑制率与年龄呈负相关(P<0.01)、与TG(甘油三酯)检测结果呈正相关(P<0.01),患者AA抑制率与相关检验结果无相关性(P>0.05);结论 ADP抑制率时应考虑患者年龄及TG综合分析,在ADP抑制率疗效上替格瑞洛的使用是有显著效果的,AA抑制率疗效上阿司匹林使用效果明显。Objective To retrospectively analyze the influencing factors of arachidonic acid(AA)and adenosine diphosphate(ADP)inhibition rates and the efficacy of different antiplatelet drugs.Methods A total of 114 patients with platelet inhibition rates detected in the hospital were selected from March 2015 to December 2018.The inhibition rates of AA and ADP were divided into several groups according to the antiplatelet treatment strategies.Results The ADP inhibition rate,rather than the AA inhibition rate(P>0.05),was negatively correlated with age(P<0.01)and positively with triglyceride(TG)test results(P<0.01).Significant differences of ADP inhibition rates between groups of aspirin and aspirin+Greg los(P<0.01)and between groups of clopidogrel and aspirin+Greg los(P<0.05)were noted.Similarly,remarkable differences of AA inhibition rates between groups of aspirin and clopidogrel(P<0.01),clopidogrel and aspirin+Greg los(P<0.01),and clopidogrel and aspirin+clopidogrel(P<0.05)were seen.Conclusion A comprehensive analysis of age and TG level should be taken into account in terms of the ADP inhibitory rate detection.Greg los treatment is effective based on the ADP inhibition rate measurement while aspirin therapy is promising based on AA inhibition.

关 键 词：血栓弹力图检测 AA途径抑制率 ADP途径抑制率 

分 类 号：R331.143[医药卫生—人体生理学] R9732[医药卫生—基础医学]