干细胞、组织工程支架与神经营养因子在脊髓损伤治疗中的应用  

Application of stem cells,tissue engineering scaffolds and neurotrophic factors in the treatment of spinal cord injury

作　　者：季航宇 顾军 谢凌寒[1] 吴小涛[1] Ji Hangyu;Gu Jun;Xie Linghan;Wu Xiaotao(Department of Spinal Surgery,Zhongda Hospital,Southeast University,Nanjing 210009,Jiangsu Province,China;Department of Orthopedics,Wuxi Branch,Zhongda Hospital,Southeast University,Wuxi 214105,Jiangsu Province,China)

机构地区：[1]东南大学附属中大医院脊柱外科,江苏省南京市210009 [2]东南大学附属中大医院无锡分院骨科,江苏省无锡市214105

出　　处：《中国组织工程研究》2020年第25期4088-4093,共6页Chinese Journal of Tissue Engineering Research

基　　金：江苏大学2018年度临床医学科技发展基金(JLY20180027),项目负责人:季航宇;2018年江苏卫计委面上项目卫生厅项目(H2018023),项目负责人:顾军~~

摘　　要：背景:干细胞具有多向分化潜能,组织工程支架可以为其提供支持,神经营养因子则可以促进干细胞的分化,3者联合移植治疗方案促进脊髓损伤功能恢复是当前研究热点之一。目的:综述近年来干细胞、组织工程支架、神经营养因子及其联合移植治疗脊髓损伤的研究进展。方法:作者检索PubMed、Sciencedirect、Medline、中国知网等数据库2000年1月至2019年10月的相关文章。英文检索词为“spinal cord injury,mesenchymal stem cells,issue engineering,neurotrophic factor”,中文检索词为“脊髓损伤,间充质干细胞,组织工程,神经营养因子”,检索文献类型为研究原著,初检文章712篇,再经过严格筛选后,对符合要求的79篇文献进行分类综述。结果与结论:单纯的干细胞移植并不能重建脊髓的复杂结构和稳定性,而单纯的生物材料、神经营养因子也不能替代脊髓损伤过程中的神经元丢失,因此联合移植是脊髓损伤治疗的研究方向。但是由于脊髓损伤的部位、损伤的组织及其修复时的营养需求各异,如何将干细胞、组织工程支架、神经营养因子联合的方案最优化仍是一个巨大的挑战。BACKGROUND:Stem cells have multi-directional differentiation potential.Tissue engineering scaffolds can provide support for them.Neurotrophic factors can promote the differentiation of stem cells.The combination of the three therapies to promote the functional recovery of spinal cord injury is one of the current research hotspots.OBJECTIVE:To review the research progress of stem cells,tissue engineering scaffolds,neurotrophic factors and their combined transplantation in the treatment of spinal cord injury in recent years.METHODS:The authors searched PubMed,ScienceDirect,Medline,and CNKI for original articles from January 2000 to October 2019.The key words were“spinal cord injury,mesenchymal stem cells,issue engineering,neurotrophic factor”in English and Chinese,respectively.Totally 712 studies were retrieved.After strict screening,79 studies that met the requirements were classified and reviewed.RESULTS AND CONCLUSION:Stem cell transplantation alone cannot reconstruct the complex structure and stability of the spinal cord.Biological materials or neurotrophic factors alone cannot replace the loss of neurons during spinal cord injury.Therefore,combined transplantation is the research direction of spinal cord injury treatment.However,due to the differences in the location of spinal cord injury,the tissue of injury and the nutritional requirements of its repair,the characteristics of various stem cells,tissue engineering scaffolds and neurotrophic factors are different.How to optimize the combination of the three is still a huge challenge.

关 键 词：脊髓损伤 干细胞 间充质干细胞 组织工程 支架 神经营养因子 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]