细胞自噬在子宫腺肌病发病机制中作用的研究进展  

Advances in the Role of Autophagy in the Pathogenesis of Adenomyosis

作　　者：谢云凯 刘威[1] 白艺璇 关红卫 邹永辉(审校)[1] XIE Yun-kai;LIU Wei;BAI Yi-xuan;GUAN Hongwei;ZOU Yong-hui(Department of Gynecology,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250000,China)

机构地区：[1]山东大学附属省立医院妇科,济南250000

出　　处：《国际妇产科学杂志》2020年第2期207-211,共5页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81671434)。

摘　　要：子宫腺肌病(adenomyosis)作为女性常见疾病之一,其常见症状如痛经、经量过多对患者生活质量造成严重影响,常并发贫血甚至休克,子宫腺肌病还可导致不良妊娠及不孕症。子宫腺肌病保守治疗效果较差、较易复发,部分患者需接受手术治疗。子宫腺肌病的发病机制目前尚不明确,近年也逐渐成为妇科领域的研究热点。细胞自噬(autophagy)作为调节细胞生长代谢的重要生理机制,其在包括肿瘤在内的众多疾病的发生、发展中发挥着重要作用。近年细胞自噬在子宫腺肌病发生、发展及转归方面的作用日益引起关注,针对两者之间关系的研究也越来越多。总结自噬在子宫腺肌病中作用的最新相关研究进展,并对自噬在子宫腺肌病治疗中的潜在作用进行探讨。Adenomyosis is one of the common diseases in women.Its common symptoms,such as dysmenorrhea and excessive menstruation,often have a serious impact on the quality of life.It is usually complicated with anemia or even shock.Adenomyosis is believed to cause adverse pregnancy and infertility.The effect of conservative treatment of adenomyosis is poor and recurrence is easy.Some patients need to receive surgical treatment.The pathogenesis of adenomyosis is still unclear,and it has become a research hotspot in the field of gynecology in recent years.As an important physiological mechanism regulating cell growth and metabolism,autophagy plays an important role in the occurrence and development of many diseases including tumors.In recent years,the role of autophagy in the occurrence,development,and outcome of adenomyosis has attracted increasing attention.This paper summarizes the latest research progress on the role of autophagy in adenomyosis and discusses the potential role of autophagy in the treatment of adenomyosis.

关 键 词：子宫腺肌病 自噬 Beclin-1蛋白 TOR丝氨酸-苏氨酸激酶 

分 类 号：R711.71[医药卫生—妇产科学]