Syntheses, Crystal Structures and DNA-binding Properties of Cd(Ⅱ), Co(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) Complexes Containing Imidazolium Derivatives  

作　　者：LI Yu-Han YANG Yu GUAN Hui-Chao ZHANG Min XU Lin-Lin YUE Shu-Mei 李雨涵;杨宇;关慧超;张敏;徐林林;岳淑美(College of Chemistry,Changchun Normal University,Changchun 130032,China)

机构地区：[1]College of Chemistry,Changchun Normal University,Changchun 130032,China

出　　处：《Chinese Journal of Structural Chemistry》2020年第2期356-367,188,共13页结构化学（英文）

摘　　要：Cd(Ⅱ), Co(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) complexes(1~4) based on 2-(2-pyridyl)benzimidazole(pbm) and 4,4'-oxybisbenzoic acid(H2odc) were synthesized. The formulas of these complexes are [Cd(pbm)(odc)2](1), [Co(pbm)(odc)2](2), [Cu(pbm)(odc)2](3) and [Zn(pbm)(odc)2](4) confirmed by single-crystal X-ray diffraction analysis, which shows that complexes 1, 2 and 4 belong to monoclinic system with space group P21/n, while complex 3 belongs to monoclinic system with space group P21/c. The binding properties of complexes 1~4 with CT-DNA are evaluated by ultraviolet spectrum, fluorescence spectra and viscosity measurements. The results indicate that complexes 1~4 have strong interaction with CT-DNA binding. These complexes exhibit an electrostatic or groove mode in respect of binding with DNA, which can effectively destroy DNA. And this binding mode may be applied to the interaction between the complexes and cancer cell DNA. Therefore, we hope to provide a theoretical and scientific basis for the research of anti-cancer drugs.

关 键 词：2-(2-pyridyl)benzimidazole crystal structure CT-DNA binding 

分 类 号：O641.4[理学—物理化学]