基于ASQ评估的幼儿食物过敏与生理、心理发育关系的研究  

Studies on the Relationship Between Food Allergy and Development of Physiology and Psychology in Children Based on ASQ Evaluation

作　　者：仲越[1] ZHONG Yue(Department of Pediatrics,Nantong Maternal and Child Health Hospital,Nantong,Jiangsu,226018,China)

机构地区：[1]南通市妇幼保健院儿科,江苏南通226018

出　　处：《中国血液流变学杂志》2019年第3期334-338,360,共6页Chinese Journal of Hemorheology

基　　金：南通市科技计划项目(MS12017013-5)。

摘　　要：目的探讨基于ASQ评估基础的幼儿食物过敏与精神心理、生理受累情况的关系,为更好地合理干预食物过敏患儿提供依据.方法选择2018年1月-2018年12月确诊的0~3岁食物过敏患儿为研究组,以性别、年龄匹配的正常幼儿为对照组,ASQ-3和ASQ-SE两套评估量表/问卷进行评估,检测sIgE、IL-4、IL-6、TNF-α等免疫指标,记录食物过敏多系统受累情况.分析比较两组结果.将研究组按照ASQ评估结果分为接近或低于界值组和高于界值组,比较两组免疫指标及生理受累情况.结果两组幼儿ASQ-3中沟通、精细工作、解决问题、个人-社会四个维度分值,研究组明显低于对照组,差异有统计学意义(P<0.05);两组幼儿ASQ-SE中自我调控、依从性、沟通、适应功能、自主性、情感、人际互动七个能区分值,研究组明显低于对照组,差异均有统计学意义(P<0.05).两组幼儿sIgE、IL-4、IL-6、TNF-α比较差异有统计学意义(P<0.05),研究组指标均较对照组高.ASQ-3的沟通、精细动作、解决问题、个人-社会能区中高于界值组的sIgE、IL-4、IL-6、TNF-α指标值均高于接近或低于界值组,生理受累情况均较接近或低于界值组明显.ASQ-SE的自我调控、依从性、沟通、适应功能、自主性、情感和人际互动七个能区中高于界值组的sIgE、IL-4、IL-6、TNF-α指标值均高于接近或低于界值组,生理受累情况均较接近或低于界值组明显,差异均有统计学意义(P<0.05).结论ASQ评估量表是评估幼儿食物过敏及其身心受累情况较好的方法,根据其每个功能区界值情况,可以及时指导做好免疫指标检测及身体受累评估,为进一步诊治提供较好的依据.Objective To explore the relationship between food allergy and psychological and physiological involvement of children based on ASQ evaluation,and to provide the basis for better and reasonable intervention of children with food allergy.Methods From January 2018 to December 2018,the children with food allergy diagnosed were selected as the study group.The normal children matched by sex and age were used as the control group.ASQ-3 and ASQ-SE two assessment scales/questionnaires,and detection of slgE,IL-4,IL-6 and TNF-α in serum samples were used to record the multisystem involvement of food allergy.The results of the two groups were analyzed and compared.According to the results of ASQ evaluation,the study group was divided into two groups:close to or below the threshold group and above the boundary value group,and the immune indexes and physiological involvement of the two groups were compared.Results There were statistically significant differences in communication,delicate operation,problem-solving,personal-social four dimensions in the two groups of children ASQ-3,the study group was significantly lower than the control group,P<0.05;The self-regulation,compliance,communication,adaptive function,autonomy,emotion,interpersonal interaction seven distinguishable values in the two groups of children ASQ-SE were statistically significant,the study group was significantly lower than the control group,P<0.05.The indexes of slgE,IL-4,IL-6,TNF-α in the two groups were statistically significant,P<0.05,and the indexes in the study group were higher than those in the control group.ASQ-3 communication,delicate operation,problem-solving,indexes of slgE,IL-4,IL-6,TNF-α in individual-social energy region were higher than or lower than boundary value group,physiological involvement was close to or lower than boundary value group.slgE,IL-4,IL-6,TNF-α of ASQ-SE was higher than threshold group in self-regulation,compliance,communication,adaptation function,autonomy,emotion and interpersonal interaction.The index value of TNF-�

关 键 词：幼儿 食物过敏 免疫 ASQ 心理发育 生理受累 

分 类 号：R729[医药卫生—儿科]