Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery  

作　　者：PAN Gaifang MA Yuan ZHANG Jiao GUO Yuanyuan DING Fei GE Huan LI Qifeng ZHU Xinyuan ZHANG Chian 

机构地区：[1]School of Chemistry and Chemical Engineering,State Key Laboratory of Metal Matrix Composites,Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing,Shanghai Jiao Tong University,Shanghai 200240,P.R.China [2]Department of Paediatric Neurosurgery,Xinhua Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200092,P.R.China

出　　处：《Chemical Research in Chinese Universities》2020年第2期274-280,共7页高等学校化学研究（英文版）

基　　金：Supported by the National Key Research and Development Program of China(Nos.2018YFC1106100,2018YFC1106102);the National Natural Science Foundation of China(Nos.21661162001,21673139,51690151,51473093,51973112);the Special Program for Collaborative Innovation in Shanghai University of Medicine&Health Sciences,China(No.SPCI-17-15-001);the Program of Shanghai Medical Professionals Across Subject Funds,China(No.YG2016MS74).

摘　　要：Herein,we report a geometrically well-defined prism assembled by two floxuridine(F)integrated RNA strands as a precise nanomedicine for chemodrug delivery.Owing to the similarity between chemotherapeutic F and uridine(U),all uridines in the component RNA strands are replaced by F during their in vitro transcription syntheses.By specifically designing their sequences,F-containing S-shape tiles with the single-stranded loops are constructed and then further assemble into the RNA prism through T-junction interactions and sticky-end cohesions.The present study demonstrates that the F-integrated RNA prism can serve as an efficient platform for chemodrug delivery and anticancer treatment.We believe that the study would help the future development of RNA-based nanomedicine in various applications.

关 键 词：SELF-ASSEMBLY FLOXURIDINE RNA PRISM PRECISE nanodrug Drug delivery 

分 类 号：TB383[一般工业技术—材料科学与工程]