小剂量阿司匹林肠溶片联合拉贝洛尔在妊娠期高血压患者治疗中的应用及对患者凝血功能的影响  

Application of low-dose aspirin enteric-coated tablets combined with labetalol in the treatment of patients with pregnancyinduced hypertension and its effects on coagulation function of patients

作　　者：陈美玉 梁梅芬 陈雪飞 CHEN Meiyu;LIANG Meifen;CHEN Xuefei(Maternal and Child Health Hospital of Zengcheng District,Guangdong,Guangzhou 511300,China)

机构地区：[1]广州市增城区妇幼保健院,广东广州511300

出　　处：《中国医药科学》2020年第5期62-65,共4页China Medicine And Pharmacy

摘　　要：目的探讨小剂量阿司匹林肠溶片联合拉贝洛尔在妊娠期高血压患者治疗中的应用及对患者凝血功能的影响。方法将2016年1月~2019年1月我院收治的100例妊娠期高血压患者采用随机数字表法分为对照组和观察组。其中对照组患者给予拉贝洛尔进行治疗,观察组在对照组基础上加用小剂量阿司匹林肠溶片进行治疗。比较两组患者治疗2周后的临床疗效和妊娠结局,分析其治疗前及治疗2周后的血压水平和凝血功能指标。结果观察组患者治疗2周后的临床总有效率为96.00%,相比与对照组的80.00%显著增加,差异有统计学意义(P<0.05)。观察组患者治疗2周后舒张压和收缩压水平相比于对照组显著降低,差异有统计学意义(P<0.05)。观察组者治疗2周后PT、APTT、TT相比于对照组显著升高;Fib和D-D相比于对照组显著降低,差异有统计学意义(P<0.05)。观察组患者分娩时不良妊娠结局率为4.00%,与对照组的22.00%比较显著降低,差异有统计学意义(P<0.05)。结论在妊娠期高血压患者治疗中应用小剂量阿司匹林肠溶片联合拉贝洛尔疗效显著,能够明显改善患者凝血功能,不良妊娠结局率低,值得在临床上大力推广。Objective To investigate the application of low-dose aspirin enteric-coated tablets combined with labetalol in the treatment of patients with pregnancy-induced hypertension and its effects on coagulation function of patients.Methods 100 patients with pregnancy-induced hypertension admitted and treated in our hospital from January 2016 to January 2019 were equally divided into the control group and the observation group using the random number table method.The patients in the control group were treated with labetalol,while the observation group was treated with low-dose aspirin enteric-coated tablets on the basis of the control group.The clinical efficacy and pregnancy outcome of the two groups were compared after 2 weeks treatment,and the blood pressure level and coagulation function indexes were analyzed before and after 2 weeks treatment.Results The overall clinical response rate of patients in the observation group after 2 weeks of treatment was 96.00%,which was significantly increased compared with that of the control group(80.00%)(P<0.05).The diastolic and systolic blood pressure levels of patients in the observation group after 2 weeks treatment were significantly lower than those in the control group(P<0.05).PT,APTT and TT of patients in the observation group after 2 weeks treatment were significantly higher than those in the control group;Fib and D-D were significantly increased compared with the control group(P<0.05).The adverse pregnancy outcome rate of patients in the observation group was 4.00%,which was significantly lower than that in the control group(22.00%),with statistically significant difference(P<0.05).Conclusion The application of low-dose aspirin enteric-coated tablets combined with labetalol in the treatment of patients with pregnancy-induced hypertension is significant in efficacy,and can significantly improve the coagulation function of patients,with a low adverse pregnancy outcome rate,which is worthy of vigorous clinical promotion.

关 键 词：阿司匹林肠溶片 拉贝洛尔 妊娠期高血压 妊娠结局 凝血功能 

分 类 号：R714.246[医药卫生—妇产科学]