唑来膦酸对女性骨质疏松症的疗效及对骨标志物的影响研究  

Research on the effect of zoledronic acid in the treatment of osteoporosis in women and its effect on bone markers

作　　者：王鸿儒 杨晓梅 Wang Hongru;Yang Xiaomei(Orthopaedic Hospital of Guizhou Province,Guizhou Guiyang 550007)

机构地区：[1]贵州省骨科医院,贵州贵阳550007

出　　处：《中国社区医师》2020年第10期36-37,共2页Chinese Community Doctors

摘　　要：目的:探讨唑来膦酸对女性骨质疏松症的疗效及对骨标志物的影响。方法:2018年1月-2019年1月收治骨质疏松症患者120例,按疾病类型分为两组,各60例。对照组为继发性骨质疏松症患者,给予骨化三醇软胶囊及朗迪碳酸钙D3片治疗。试验组为原发性骨质疏松症患者,在对照组基础上给予唑来膦酸治疗。比较两组临床疗效及骨标志物各项指标水平。结果:试验组治疗后腰椎及髋部骨密度均显著提升,与治疗前比较差异有统计学意义(P<0.05)。对照组治疗后L2、L3、L4、L1~4及髋部平均骨密度增加明显,与治疗前比较差异有统计学意义(P<0.05)。两组患者腰椎以及髋部骨密度值比较,差异无统计学意义(P>0.05)。两组患者治疗前血浆钙、血磷、BUN、Cr等指标水平比较,差异无统计学意义(P>0.05)。试验组治疗后血磷水平显著高于对照组,差异有统计学意义(P<0.05);两组血浆钙含量、BUN、Cr水平比较,差异无统计学意义(P>0.05)。两组治疗前P1NP、β-CTX、N-MID、25-OH-VD水平比较,差异无统计学意义(P>0.05);治疗后试验组各指标水平均优于对照组,差异有统计学意义(P<0.05)。结论:对于不同原因导致的女性骨质疏松症患者采用唑来膦酸治疗,具有显著的临床疗效,且能改善骨标志物水平。Objective:To research the effect of zoledronic acid in the treatment of osteoporosis in women and its effect on bone markers.Methods:From January 2018 to January 2019,120 cases of osteoporosis were enrolled,they were divided into two groups according to disease types with 60 cases in each group.Secondary osteoporosis group was as a control group,they were treated with calcitriol soft capsules and Reneed calcium carbonate D3 tablets;Primary osteoporosis group was as the experimental group,they were given zoledronic acid on the basis of calcitriol soft capsules and Reneed calcium carbonate D3 tablets.The clinical efficacy of the two groups and the indexes of bone markers were compared.Results:The bone density of lumbar vertebrae and hip were increased,the levels of bone markers such as pro-collagenⅠN-terminal peptide(P1NP),beta-adhesive degradation product(β-CTX)and human N-terminal mid-osteocalcin(N-MID)decreased significantly,25 hydroxyvitamin D(25-OH-VD)significantly increased.The average bone density of L2、L3、L4、L1~4 and hip increased significantly in the control group after treatment,the levels of P1NP、β-CTX and N-MID decreased significantly.The N-MID level in the experimental group was significantly lower than in the control group,the difference was statistically significant(P<0.05).Conclusion:The effect of zoledronic acid in women with osteoporosis which caused by different reasons can be relatively significant.

关 键 词：唑来膦酸 女性骨质疏松症 骨标志物 

分 类 号：R580[医药卫生—内分泌]