老年女性血清Ⅰ型胶原羧基端肽独立影响因素的研究  

Factors associated with serum C-terminal telopeptide of typeⅠcollagen level in elderly women

作　　者：张柳娟[1] 寿燕琼 边平达[1] 陈锦平[3] ZHANG Liujuan;SHOU Yanqiong;BIAN Pingda(Department of Geriatrics,Zhejiang Provincial People’s Hospital(People’s Hospital of Hangzhou Medical College),Hangzhou 310024,China)

机构地区：[1]浙江省人民医院(杭州医学院附属人民医院)老年医学科,杭州310024 [2]浙江省人民医院(杭州医学院附属人民医院)输液室,杭州310024 [3]浙江省人民医院(杭州医学院附属人民医院)骨科,杭州310024

出　　处：《浙江医学》2020年第5期437-440,共4页Zhejiang Medical Journal

基　　金：浙江省医药卫生平台重点资助计划项目(2016ZDA002)。

摘　　要：目的寻找老年女性血清Ⅰ型胶原羧基端肽(CTX)的独立影响因素。方法对212例老年女性进行伴随疾病和生活方式的调查,并进行骨代谢标志物(CTX、甲状旁腺素和25-羟基维生素D)、血液生化等指标的检测,运用多元回归分析方法筛选老年女性血清CTX的独立影响因素。结果老年女性血清CTX的独立影响因素包括血钠(β=20.879,P<0.01)、服用钙剂(β=-100.381,P<0.01)、室外运动(β=-42.459,P<0.05)和总胆固醇(β=34.696,P<0.05)。结论坚持低盐饮食、室外运动和服用钙剂,降低血清总胆固醇水平,可能是降低老年女性血清CTX水平的重要方法。Objective To investigate factors associated with serum C-terminaltelopeptide of type Ⅰ collagen(CTX) level in elderly women.Methods A cross-sectional survey was conducted in a cohort comprising 212 elderly women.All subjects underwent a survey on underlying chronic diseases and lifestyle factors.The serum levels of bone metabolism markers(CTX),parathyroid hormone,25-hydroxyvitamin D),and biomedical index were detected.Univariate analysis and multivariate regression analysis were performed to discover independent factors associated with CTX.Results It was showed that serum sodium(β=20.879,P<0.01),calcium compound supplementation(β=-100.38 1,P<0.01),outdoor exercise(β=-42.459,P<0.05) and total cholesterol(β=34.696,P<0.05) were independent fa ctors associated with serum CTX in elderly women.Conclusion Low-salt diet,outdo or exercise,calcium compound supplementation and lowering total cholesterol may reduce serum CTX level in elderly women.

关 键 词：I型胶原羧基端肽 血钠 胆固醇 老年女性 

分 类 号：R580[医药卫生—内分泌]