雌孕激素复合制剂口服与阴道放置方案对行冻融胚胎移植薄型子宫内膜患者子宫内膜厚度及妊娠结局的影响  

Effects of Oral and Vaginal Placement of Estrogen Progesterone Compound on Endometrial Thickness and Pregnancy Outcome in Patients with Thin Endometrium Undergoing Freeze-thawed Embryo Transfer

作　　者：陈熙琳[1] 武泽[1] CHEN Xilin;WU Ze(The First People’s Hospital of Yunnan,Kunming 650000,China)

机构地区：[1]云南省第一人民医院,云南昆明650000

出　　处：《中外医学研究》2020年第7期25-27,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：云南省第一人民医院人类辅助生殖技术研究省创新团队项目(项目编号:2017HC009)。

摘　　要：目的:探讨雌二醇/雌二醇地屈孕酮(芬吗通)不同给药途径对行胚胎移植薄型子宫内膜患者子宫内膜厚度及妊娠结局的影响。方法:研究对象为笔者所在医院2017年3月-2018年3月收治的196例行胚胎移植薄型子宫内膜患者。采用随机数字表法将其分为对照组和观察组,每组98例。对照组于月经周期3 d后口服雌二醇/雌二醇地屈孕酮治疗,观察组于月经周期5 d后将雌二醇/雌二醇地屈孕酮置于阴道治疗。比较两组患者子宫内膜厚度、用药剂量、胚胎情况及妊娠结局。结果:治疗后,两组子宫内膜厚度均较治疗前明显增加(P<0.05),但两组治疗后子宫内膜厚度比较差异无统计学意义(P>0.05)。观察组用药剂量明显少于对照组,差异有统计学意义(P<0.05)。两组患者优质胚胎率、胚胎种植率比较差异无统计学意义(P>0.05)。观察组临床妊娠率明显高于对照组,差异有统计学意义(P<0.05)。结论:行冻融胚胎移植薄型子宫内膜患者通过阴道途径给予雌二醇/雌二醇地屈孕酮与口服途径一样能增厚子宫内膜,胚胎移植情况良好,优势在于减少药物用量,从而降低可能的并发症,改善妊娠结局。Objective:To investigate the effects of different routes of Estradiol/Estradiol Diprogesterone(Fentonone)on endometrial thickness and pregnancy outcome in patients with thin endometrium undergoing embryo transfer.Method:The study subjects were 196 patients with thin endometrium undergoing embryo transfer admitted in our hospital from March 2017 to March 2018.According to the random number table method,They were divided into the control group and the observation group,98 cases in each group.The control group was treated with oral Estradiol/Estradiol Diprogesterone after 3 days of menstrual cycle.In the observation group,Estradiol/Estradiol Diprogesterone was placed in vagina after 5 days of menstrual cycle.The endometrial thickness,drug dosage,embryo status,and pregnancy outcome were compared between the two groups.Result:After treatment,endometrial thickness in both groups increased significantly compared with that before treatment(P<0.05),but there was no significant difference between the two groups after treatment(P>0.05).The drug dosage of the observation group was significantly less than that of the control group,the difference was statistically significant(P<0.05).There were no significant differences between the two groups in quality embryo rate and embryo implantation rate(P>0.05).The clinical pregnancy rate in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Patients with thin endometrium undergoing freeze-thawed embryo transfer through the vaginal route by using Estradiol/Estradiol Diprogesterone can increase the endometrium as well as the oral route.The embryo transfer is good,with the advantage of reducing drug dosage,so as to reduce possible complications and improve pregnancy outcome.

关 键 词：阴道给药途径 雌二醇 子宫内膜厚度 胚胎移植 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]