禽疱疹病毒活载体疫苗研究进展  

Research Progress on Live Vectored Vaccine of Avian Herpes Virus

作　　者：王梦阁 吴英 程安春[1] 汪铭书[1] 朱德康[1] 贾仁勇[1] 刘马峰[1] 陈舜[1] 赵新新 杨乔[1] 张沙秋 黄娟[1] 刘韵雅 张玲 于艳玲 WANG Mengge;WU Ying;CHENG Anchun;WANG Mingshu;ZHU Dekang;JIA Renyong;LIU Mafeng;CHEN Shun;ZHAO Xinxin;YANG Qiao;ZHANG Shaqiu;HUANG Juan;LIU Yunya;ZHANG Ling;YU Yanling(Institute of Preventive Veterinary Medicine?Animal Epidemic Disease and Human Health Sichuan Provincial Key Laboratory,Poultry Disease Prevention and Control Research Center Sichuan Agricultural University,Chengdu 611103,China)

机构地区：[1]四川农业大学动物医学院禽病防治研究中心,预防兽医研究所,动物疫病与人类健康四川省重点实验室,成都611130

出　　处：《中国农业科技导报》2020年第3期85-93,共9页Journal of Agricultural Science and Technology

基　　金：国家重点研发计划项目(2017YFD0500800);国家自然科学基金项目(31602079);现代农业产业技术体系专项(CARS-42-17);四川省教育厅重点项目(17ZA0309);四川省科技厅苗子工程项目(2017-2018)。

摘　　要：禽疱疹病毒主要包括α疱疹病毒亚科的鸡马立克氏病毒(Marek’s disease virus,MDV)、传染性喉气管炎病毒(infectious laryngotracheitis virus,IBDV)和鸭肠炎病毒(duck enteritis virus,DEV)。作为疱疹病毒家族的成员,禽疱疹病毒基因组庞大,存在多个复制非必需区,可容纳多个外源基因的插入,是表达其他禽类病原抗原基因的理想载体。总结了禽疱疹病毒的构建方法、外源基因表达水平,并对MDV、IBDV和DEV三种禽疱疹病毒的不同重组病毒疫苗免疫效果评价进行归纳,旨在为畜禽传染病防治提供参考依据。Avian herpesvirus mainly includes Marek’s disease virus(MDV),infectious laryngotracheitis virus(IBDV)and duck enteritis virus(DEV),which all belong toα-herpes virus subfamily.As a member of the herpesvirus family,avian herpesvirus has a huge genome,and it has many replication non-essential regions,which can accommodate the insertion of multi-exogenous genes.Thus it is an ideal vector for expressing other avian pathogenic antigen genes.This paper summarized the construction method and expression level of exogenous gene of avian herpesvirus,the immune effect evaluation of different recombinant virus vaccines of MDV,IBDV and DEV was summarized as well,thus providing reference for the prevention and control of infectious diseases in livestock and poultry.

关 键 词：禽疱疹病毒 活载体疫苗 MDV IBDV DEV 

分 类 号：S852.65[农业科学—基础兽医学]