新生儿先天性甲状腺功能减低症筛查中游离甲状腺素与促甲状腺素联合检测的价值研究  被引量:3

Study on the Value of Combined Detection of Free Thyroxine and Thyrotropin in the Screening of Neonatal Congenital Hypothyroidism

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作  者:冷红 LENG Hong(Suizhou Maternal and Child Health Hospital,Suizhou 441300,China)

机构地区:[1]随州市妇幼保健院,湖北随州441300

出  处:《中外医学研究》2020年第6期61-63,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘  要:目的:探究在新生儿先天性甲状腺功能减低症(CH)筛查中应用游离甲状腺素(FT4)联合促甲状腺素(TSH)检测的临床应用效果。方法:选取2017年5月-2018年8月在笔者所在医院出生的26895例新生儿,采用TSH联合FT4进行检测。对新生儿初筛时干血滤纸片、复查时干血滤纸片、复查时血清FT4和TSH水平进行对比。结果:26895例新生儿通过进行阳性筛查共召回126例,被诊断为原发性CH的患者有8例,未筛查到患有中枢性CH,筛查出患有高TSH血症有3例。阳性筛查共召回126例新生儿,复查时干血滤纸片FT4和TSH水平均低于初筛时干血滤纸片,差异有统计学意义(P<0.05)。复查时血清与复查时干血滤纸片FT4、TSH水平比较,差异均无统计学意义(P>0.05)。原发性CH患儿初筛时干血滤纸片、复查时干血滤纸片及复查时血清FT4和TSH水平比较,差异均无统计学意义(P>0.05)。126例新生儿初筛时干血滤纸片FT4、TSH水平与复查时干血滤纸片结果均呈正相关(r=0.431、0.568,P<0.05);复查时血清FT4、TSH水平与复查时干血滤纸片结果呈正相关(r=0.476、0.688,P<0.05)。原发性CH患儿复查时血清FT4、TSH水平与复查时干血滤纸片结果呈正相关(r=0.596、0.725,P<0.05)。结论:在新生儿先天性甲状腺功能减低症筛查中应用干血滤纸片TSH联合FT4筛查方法,能够及早发现患儿病情,为疾病治疗提供依据,从而提升疾病治疗效果。Objective:To investigate the clinical effect of free thyroid(FT4)combined with thyrotropin(TSH)detection in the screening of neonatal congenital hypothyroidism.Method:A total of 26895 neonates born in our hospital from May 2017 to August 2018 were selected and tested by TSH combined with FT4.The levels of FT4 and TSH of neonates were compared between dry blood filter paper at initial screening,dry blood filter paper at reexamination and serum at reexamination.Result:A total of 126 cases of 26895 neonates were recalled through positive screening,and 8 of the patients were diagnosed with primary CH,but no central CH was detected,and 3 of the patients were diagnosed with hyper TSH.A total of 126 neonates were recalled through positive screening,and the FT4 and TSH levels of the dry blood filter paper at reexamination were lower than those of the dry blood filter paper at initial screening,the differences were statistically significant(P<0.05).There were no significant differences in FT4 and TSH between serum at reexamination and dry blood filter paper at reexamination(P>0.05).There were no significant differences between the dry blood filter paper at initial screening,dry blood filter paper at reexamination and serum at reexamination(P>0.05).There was a positive correlation between the levels of FT4 and TSH of the dry blood filter paper at initial screening of 126 neonates and the results of the dry blood filter paper at reexamination(r=0.431,0.568,P<0.05).There was a positive correlation between the levels of FT4 and TSH of the serum at reexamination and the results of the dry blood filter paper at reexamination(r=0.476,0.688,P<0.05).Conclusion:The application of dry blood filter paper TSH combined with FT4 screening method in the screening of neonatal congenital hypothyroidism can find out the condition of the children as soon as possible,provide the basis for the treatment of the disease and improve the therapeutic effect of the disease.

关 键 词:促甲状腺素 游离甲状腺素 先天甲状腺减低症 干血滤纸片 

分 类 号:R722.1[医药卫生—儿科]

 

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