右美托咪啶对妇科腔镜术后肠功能的影响  

Effect of Dexmetomidine on Intestinal Function after Gynecological Laparoscope Surgery

作　　者：黄海娟[1] 陆辉 朱旭[1] 冯水土 HUANG Haijuan;LU Hui;ZHU Xu;FENG Shuitu(Xiamen Traditional Chinese Medicine Hospital,Xiamen 361000,China;不详)

机构地区：[1]厦门市中医院,福建厦门361000 [2]厦门市海沧医院

出　　处：《中外医学研究》2020年第8期6-8,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：厦门市科技计划(医疗卫生项目)(项目编号:3502Z20184049)。

摘　　要：目的:研究行妇科腔镜手术患者静脉泵注右美托咪啶对术后肠功能的影响.方法:选取2016年9月-2018年11月行妇科腔镜手术的90例患者,将其随机分为甲、乙、丙三组,各30例.甲组患者麻醉诱导前15 min内静脉泵注0.9%氯化钠注射液5 ml;乙组静脉泵注0.3μg/kg的右美托咪啶;丙组则静脉泵注0.5μg/kg的右美托咪啶.比较三组T1~T5血浆丙泊酚浓度、术后肠功能恢复情况、血白细胞、CRP、PCT水平、术中心率及平均动脉压、不良反应发生情况.结果:乙、丙组术后首次排气时间均早于甲组,且丙组早于乙组,差异均有统计学意义(P<0.05).乙、丙组BFI≤28.8分占比均高于甲组,且丙组高于乙组,差异均有统计学意义(P<0.05).乙、丙组恶心呕吐发生率均低于甲组,但乙组与丙组比较差异无统计学意义(P>0.05).三组肠鸣音恢复时间、术中心率及平均动脉压比较差异均无统计学意义(P>0.05).T1~T5乙组和丙组血浆丙泊酚靶浓度显著低于甲组,差异有统计学意义(P<0.05);但乙组和丙组比较差异无统计学意义(P>0.05).甲组术后3 d血白细胞、CRP、PCT水平均显著高于乙组和丙组,差异有统计学意义(P<0.05),但乙组与丙组比较差异无统计学意义(P>0.05).甲组与丙组不良反应发生率高于乙组(P<0.05),但甲组与丙组比较差异无统计学意义(P>0.05).结论:行妇科腔镜手术患者,静脉泵注0.5μg/kg的右美托咪啶,可促进术后肠功能恢复效率.Objective:To investigate the effect of intravenous infusion of Dexmedetomidine on postoperative intestinal function in patients undergoing gynecological laparoscope surgery.Method:A total of 90 patients who underwent gynecological laparoscope surgery from September 2016 to November 2018 were selected and randomly divided into group A,group B and group C,30 cases in each group.In group A,5 ml of 0.9%sodium chloride was injected intravenously within 15 minutes before anesthesia induction.In group A,5 ml of 0.9%Sodium Chloride was injected intravenously 15 minutes before anesthesia induction.In group B,0.3μg/kg of Dexmedetomidine was injected intravenously.In group C,0.5μg/kg of Dexmedetomidine was injected intravenously.The plasma Propofol concentration of T1 to T5,postoperative recovery of intestinal function,white blood cell,CRP,PCT level,operative center rate and mean arterial pressure and adverse reactions were compared among the three groups.Result:The first time of postoperative exhaust in group B and group C was earlier than that in group A,and group C was earlier than that in group B,and the differences were statistically significant(P<0.05).The proportion of BFI≤28.8 points in groups B and C was higher than that in group A,and group C was higher than that in group B,and the differences were statistically significant(P<0.05).The incidence of nausea and vomiting in groups B and C was lower than that in group A,but there was no significant difference between group B and group C(P>0.05).There were no significant differences in bowel sound recovery time,operative center rate and mean arterial pressure among the three groups(P>0.05).The plasma Propofol concentration of T1 to T5 in group B and C were significantly lower than those in group A,and the difference was statistically significant(P<0.05),but there was no significant difference between group B and group C(P>0.05).The levels of white blood cells,CRP,and PCT in group A were significantly higher than those in group B and group C at 3 d after surgery,and

关 键 词：右美托咪啶 腹腔镜 肠功能 

分 类 号：R614[医药卫生—麻醉学]