重组人脑利钠肽辅助治疗老年急性心力衰竭的临床效果观察  

Clinical effects of recombinant human brain natriuretic peptide in the adjuvant treatment for elderly patients with acute heart failure

作　　者：周丽燕 王飞飞[2] 汤小芳[3] ZHOU Li-yan;WANG Fei-fei;TANG Xiao-fang(Department of Pharmaceutical Sciences,People's Hospital Affiliated to Hangzhou Medical College,Zhejiang Provincial People's Hospital,Hangzhou,Zhejiang 310014,China;不详)

机构地区：[1]浙江省人民医院杭州医学院附属人民医院药学部,浙江杭州310014 [2]浙江省人民医院望江山院区五病区,浙江杭州310009 [3]浙江医院老年综合病房,浙江杭州310013

出　　处：《中国卫生检验杂志》2020年第5期521-523,528,共4页Chinese Journal of Health Laboratory Technology

基　　金：浙江省自然科学基金(LY16H270012)。

摘　　要：目的探讨人脑利钠肽(rhBNP)辅助治疗老年急性心力衰竭(AHF)临床效果。方法收集95例临床确诊的AHF老年患者,按随机数字表法分为对照组(n=47)和观察组(n=48),对照组患者仅采用常规抗心力衰竭治疗,观察组患者在常规治疗基础上,辅助应用rhBNP。连续治疗7 d后,比较2组患者治疗前后血清BNP、炎性因子水平、心功能和肾功能变化。结果观察组患者临床疗效优于对照组(P<0.05),治疗前2组上述指标水平差异无统计学意义(P>0.05)。观察组治疗后血清BNP、高敏C-反应蛋白、白细胞介素-6、血肌酐和尿素氮水平均低于对照组,差异均有统计学意义(P<0.05);24 h尿量、左心室射血分数(LVEF)高于对照组,差异均有统计学意义(P<0.05)。结论 rh BNP辅助治疗急性心力衰竭,可有效降低患者的血清BNP和炎性因子水平,对改善心功能、肾功能具有一定的临床价值。Objective To observe the clinical effect of recombinant human brain natriuretic peptide(rh BNP) in the adjuvant treatment for elderly patients with acute heart failure(AHF).Methods Totally 95 older patients diagnosed with AHF disease were retrospectively analyzed and randomly divided into control group(n = 47) and observation group(n = 48) using random number table method.Patients in control group were treated with conventional anti-heart failure therapy,and patients in observation group were treated with rh BNP on the basis of routine treatment.After 7 days of treatment,the serum BNP and inflammatory factors level,cardiac and renal function were compared between the two groups before and after treatment.Results Clinical effect of observation group was statistically significantly better than that of control group(P<0.05).Before treatment,there was no statistical significance on the difference in detected parameters between the two groups(P>0.05).After treatment,serum BNP,hs-CRP,IL-6,SCr and ureanitrogen(BUN) were statistically significantly lower than that of control group(P<0.05),while 24 h urine volume and left ventricular ejection fraction(LVEF) in observation group were higher than those of control group(P<0.05).Conclusion Recombinant human brain natriuretic peptide(rh BNP) based on the conventional treatment can effectively reduce the serum BNP and inflammatory factors and improve the cardiac and renal function.

关 键 词：急性心力衰竭 重组人脑利钠肽 炎性因子 心功能 肾功能 

分 类 号：R541.6[医药卫生—心血管疾病]