海洋放线菌抗肿瘤活性物质的研究进展  

Research progress on the bioactive substances of marine actinomycetes and their antitumor activities

作　　者：丁衍 苏雨欣 庞启华[1] DING Yan;SU Yu-xin;PANG Qi-hua(Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization,School of Life Sciences,South China Normal University,Guangzhou 510631,China)

机构地区：[1]华南师范大学生命科学学院,广东省药食生物资源加工及综合利用工程技术研究中心,广州510631

出　　处：《天然产物研究与开发》2020年第2期323-333,357,共12页Natural Product Research and Development

基　　金：广东省自然科学基金博士启动项目(S2011040005772)。

摘　　要：放线菌是一种重要的微生物资源,海洋放线菌代谢产物的开发利用在微生物新药研究领域占据了重要的地位。本文根据所查阅的2015年以来的研究论文,对不同来源的产生抗肿瘤活性物质的海洋放线菌的种属、活性化学物质种类和结构特征、以及抗肿瘤作用进行综述。文中涉及链霉菌属及其他稀有放线菌共42种,报道了海洋放线菌产生的76个不同种类的活性化合物,它们分别具有多种抗肿瘤作用。本文对海洋放线菌抗肿瘤活性物质的研究中存在的问题提出了解决办法和建议。Actinomycetes are an important microbial resource.Actinomycetes and their bioactive substances have become the focus of drug research and development.Based on the papers we researched since 2015,we reviews the species,origin,classification of bioactive substances,chemical structure and antitumor effects of marine actinomycetes producing antitumor bioactive substances.In this paper,42 species of Streptomyces and other rare actinomycetes are involved.76 different kinds of bioactive compounds are reported which have various antitumor effects.This paper points out the problems in the research and development of antitumor bioactive substances derived from actinomycetes,and proposes solutions to the problems.

关 键 词：海洋 放线菌 活性物质 抗肿瘤 

分 类 号：R284[医药卫生—中药学]