血浆CPP、PTX3水平对稳定性冠心病患者冠状动脉狭窄的诊断价值  

Diagnostic value of plasma CPP and PTX3 levels for coronary stenosis in patients with stable coronary heart disease

作　　者：林朴卿 齐悦 张良珍 杨秦南 LIN Puqing;QI Yue;ZHANG Liangzhen;YANG Qinnan(Clifford Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 511495,China;不详)

机构地区：[1]广州中医药大学祈福医院,广州511495 [2]广州市第一人民医院

出　　处：《山东医药》2020年第10期27-31,共5页Shandong Medical Journal

基　　金：广东省医学科研基金项目(A2017079)。

摘　　要：目的探讨血浆和肽素(CPP)、正五聚蛋白3(PTX3)水平对稳定性冠心病患者冠状动脉狭窄的诊断价值。方法选择131例稳定性冠心病患者,根据冠状动脉造影结果将患者分为两组,A组(50.00%≤冠状动脉狭窄率<70.00%)69例,B组(冠状动脉狭窄率≥70.00%)62例。比较两组血浆CPP、PTX3水平,采用Logistic回归分析血浆CPP、PTX3与稳定性冠心病患者冠状动脉狭窄的关系,采用受试者工作特征(ROC)曲线分析血浆CPP、PTX3对稳定性冠心病患者冠状动脉狭窄的诊断价值。结果A组血浆CPP、PTX3水平低于B组(P<0.05),Logistic回归分析结果显示血浆CPP、PTX3是稳定性冠心病患者冠状动脉狭窄率≥70.00%的危险因素(P均<0.05),ROC曲线分析显示CPP、PTX3、CPP+PTX3诊断稳定性冠心病患者冠状动脉狭窄率≥70.00%的曲线下面积分别为0.641、0.758、0.872,敏感性分别为62.90%、69.57%、80.65%,特异性分别为72.58%、75.36%、88.41%。结论血浆CPP、PTX3水平升高与稳定性冠心病患者冠状动脉狭窄程度有关,血浆CPP、PTX3联合检测有助于稳定性冠心病患者冠状动脉狭窄的诊断。Objective To investigate the diagnostic value of plasma copeptin(CPP)and pentraxin 3(PTX3)levels for coronary stenosis in patients with stable coronary heart disease.Methods Totally 131 patients with stable coronary heart disease were selected and divided into two groups according to coronary angiography results:69 patients in group A(50.00%≤coronary stenosis rate<70.00%)and 62 patients in group B(coronary stenosis rate≥70.00%).The difference of plasma CPP and PTX3 levels between the two groups was compared.Logistic regression was used to analyze the relationship between CPP and PTX3 and coronary artery stenosis in stable coronary heart disease patients.The receiver operator characteristics curve(ROC)was used to analyze the diagnostic value of CPP and PTX3 for coronary artery stenosis in stable coronary heart disease patients.Results Plasma CPP and PTX3 levels in the group A were lower than those in the group B(both P<0.05).Logistic regression analysis showed that CPP and PTX3 were risk factors for patients with stable coronary artery stenosis rate≥70.00%(both P<0.05).ROC analysis results showed that the AUC of CPP,PTX3,and CPP+PTX3 in diagnosing coronary stenosis rate≥70.00%was 0.641,0.758 and 0.872,respectively,with sensitivities of 62.90%,69.57%and 80.65%,and specificities of 72.58%,75.36%and 88.41%,respectively.Conclusion Elevated plasma levels of CPP and PTX3 are related to the degree of coronary artery stenosis in patients with stable coronary heart disease,and the combined detection of CPP and PTX3 helps to diagnosis the coronary stenosis of patients with stable coronary heart disease.

关 键 词：稳定性冠心病 冠状动脉狭窄 和肽素 正五聚蛋白3 

分 类 号：R541.4[医药卫生—心血管疾病]