头孢西丁钠产业化工艺研究  

Study on industrialization of cefoxitin sodium

作　　者：管海英 GUAN Haiying(Shanghai SPH New Asia Pharmaceutical Co.,Ltd.,Shanghai 201203,China)

机构地区：[1]上海上药新亚药业有限公司技术中心,上海201203

出　　处：《上海医药》2020年第7期62-64,77,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:建立工业化合成头孢西丁钠的方法。方法:以头孢噻吩为起始原料,通过甲氧基化、去乙酰化、氨甲氧酰化三步反应合成头孢西丁钠。结果:本方法减少副反应和水解、降解反应的发生,降低产品杂质,提高产品质量和收率,且产品质量稳定。结论:工艺操作简单,更适宜于工业化生产。Objective:To establish a method for industrial synthesis of cefoxitin sodium.Methods:Cefoxitin sodium was synthesized using cefothiophene as starting material by methoxylation,deacetylation and aminomethoxy acylation.Results:The side reaction and hydrolysis and degradation were controlled in the reaction process,impurity was reduced,and its yield and quality were improved,and furthermore the quality of the product could be kept stable.Conclusion:This process is simple,easy to operate and more suitable for industrial production.

关 键 词：头孢噻吩 合成 头孢西丁 

分 类 号：TQ465.91[化学工程—制药化工]