绝经前与绝经后妇女血清硬化素水平的变化及其相关影响因素  

Changes of serum sclerostin levels in premenopausal and postmenopausal women and its related influencing factors

作　　者：王贤武 周士进 徐毅[2] WANG Xianwu;ZHOU Shijin;XU Yi(Department of Orthopedics,Pingbaying Branch of Xianfeng People’s Hospital,Xianfeng Hubei 445600;Department of Orthopedics,Jingzhou Second People's Hospital,Jingzhou Hubei 434000,China)

机构地区：[1]咸丰县人民医院坪坝营分院骨外科,湖北咸丰445600 [2]荆州市第二人民医院骨科,湖北荆州434000

出　　处：《临床与病理杂志》2020年第3期626-630,共5页Journal of Clinical and Pathological Research

摘　　要：目的:探究绝经前与绝经后妇女血清硬化素水平的变化及其相关影响因素。方法:纳入符合条件的绝经前和绝经后妇女各30例,检测其血清硬化素水平、相关血生化指标、性激素水平和骨转换生物标志物。采用双能X线进行股骨颈,腰椎和髋骨骨密度检测。结果:与绝经前比较,绝经后妇女雌二醇(P<0.01)、雌激素(P=0.01)、游离雌激素指数(P=0.01)和各部位骨密度均显著下降;绝经后妇女与绝经前妇女相比血清硬化素水平升高(P=0.02);由于绝经前妇女多口服避孕药,故后续数据分析仅限于绝经后妇女。绝经后妇女血清硬化素水平与游离雌激素指数(r=-0.57,P=0.01),甲状旁腺激素(r=-0.48,P=0.03)及股骨颈骨密度(r=-0.49,P=0.01)呈负相关;多元回归分析发现,游离雌激素指数(β=-0.63,P=0.01)和甲状旁腺激素(β=-0.56,P=0.01)是血清硬化素水平升高的独立危险因素。结论:绝经后妇女血清硬化素水平高于绝经前妇女。血清硬化素水平可能受到雌激素和甲状旁腺激素的调节作用。Objective: To compare the serum sclerostin levels in premenopausal and postmenopausal women and evaluate its related influencing factors. Methods: Eligible premenopausal and postmenopausal women were enrolled. And their serum sclerotin levels, related blood biochemical indicators, sex hormone levels and bone turnover biomarkers were detected. Bone mineral density(BMD) of femoral neck, lumbar spine and hip were measured by dual energy X-ray. Results: The levels of estradiol(P<0.01), estrogen(P=0.01), free estrogen index(P=0.01) and bone mineral density at all sites in postmenopausal women were lower than those in premenopausal women;the sclerotin levels in postmenopausal women were higher than those in premenopausal women(P=0.02). Since most of the premenopausal women taken oral contraceptives, subsequent analyses were limited to postmenopausal women. The serum sclerosing hormone levels in postmenopausal women were negatively correlated with the levels of free estrogen index(r=0.57, P=0.01), parathyroid hormone(r=0.48, P=0.03), and femoral neck bone mineral density(r=0.49, P=0.01). Multiple regression analysis showed that the levels of free estrogen index(β=-0.63, P=0.01), and parathyroid hormone(β=-0.56, P=0.01) were found to be the independent risk factors of sclerostin levels in postmenopausal women. Conclusion: The level of serum sclerotin in postmenopausal women is higher than that in premenopausal women. Serum sclerosing hormone levels may be regulated by estrogen and parathyroid hormones.

关 键 词：绝经前妇女 绝经后妇女 血清硬化素 

分 类 号：R580[医药卫生—内分泌]