轮状病毒肠炎患儿PCT、CRP、AGEs水平检测及其临床意义  

Detection of PCT,CRP,and AGEs levels in children with rotavirus enteritis and its clinical significance

作　　者：谢燕[1] 姜伊娟 夏利 李虹[3] XIE Yan;JIANG Yi-juan;XIA Li;LI Hong(The Second Department of Infectious Diseases,Xi'an Children's Hospital,Xi'an 710003,Shaanxi,CHINA;Xi'an Yanta Tianyou Children's Hospital,Xi'an 710065,Shaanxi,CHINA;Department of Gastroenterology,Xi'an Children's Hospital,Xi'an 710003,Shaanxi,CHINA)

机构地区：[1]西安市儿童医院感染二科,陕西西安710003 [2]西安雁塔天佑儿童医院,陕西西安710065 [3]西安市儿童医院消化科,陕西西安710003

出　　处：《海南医学》2020年第6期741-744,共4页Hainan Medical Journal

摘　　要：目的 研究轮状病毒肠炎患儿降钙素原(PCT)、C-反应蛋白(CRP)、晚期糖基化终末产物(AGEs)检测的临床价值.方法 选择2017年11月至2019年5月在西安市儿童医院住院治疗的120例轮状病毒肠炎患儿作为观察组,选取同期住院的112例普通细菌性肠炎患儿作为对照组.按脱水分度标准将观察组患儿分为轻度脱水组50例、中度脱水40例与重度脱水组30例.检测并比较观察组和对照组,以及轻度脱水组、中度脱水与重度脱水组患儿的PCT、CRP、AGEs水平.结果 观察组和对照组患儿的PCT[(8.10±0.31)ng/mL vs(0.43±0.20)ng/mL]、CRP[(15.73±3.77)mg/L vs(8.52±2.81)mg/L]、AGEs[(380.96±31.97)ng/L vs(121.98±10.76)ng/L]水平比较,观察组明显高于对照组,差异均具有统计学意义(P<0.05);观察组患儿的PCT和CRP的阳性率分别为91.67%、86.67%,明显高于对照组的19.64%、10.71%,差异均具有统计学意义(P<0.05);观察组中的重度脱水组患儿的PCT、CRP、AGEs水平明显高于中度脱水组和轻度脱水组,中度脱水组患儿的PCT、CRP、AGEs水平明显高于轻度脱水组,差异均有统计学意义(P<0.05);观察组中的重度脱水组患儿的PCT、CRP阳性率分别为93.33%、93.33%,明显高于中度脱水组的50.00%、40.00%和轻度脱水组的20.00%、16.00%,中度脱水组患儿的PCT、CRP阳性率明显高于轻度脱水组,差异均具有统计学意义(P<0.05).结论 PCT、CRP、AGEs水平检测能较准确评估轮状病毒肠炎患儿肠黏膜的损伤情况.Objective To study the application value of procalcitonin(PCT),C-reactive protein(CRP),and advanced glycation end products(AGEs)in children with rotavirus enteritis and to evaluate the damage of intestinal mucosa.Methods A total of 120 children with rotavirus enteritis treated in Xi'an Children's Hospital from November 2017 to May 2019 were selected as the observation group,and 112 children with bacterial enteritis were selected as the control group.According to the standard of dehydration degree,the observation group was divided into 50 cases of mild dehydration group,40 cases of moderate dehydration group,and 30 cases of severe dehydration group.The levels of PCT,CRP and AGEs were measured and compared between the observation group and the control group,as well as among the mild dehydration group,moderate dehydration group,and severe dehydration group,Results The levels of PCT,CRP,AGEs in the observation group were significantly higher than those in the control group(P<0.05):(8.10±0.31)ng/mL vs(0.43±0.20)ng/mL,(15.73±3.77)mg/L vs(8.52±2.81)mg/L,(380.96±31.97)ng/L vs(121.98±10.76)ng/L.The positive rates of PCT and CRP in the observation group were 91.67%and 86.67%,which were significantly higher than 19.64%and 10.71%in the control group(P<0.05).The levels of PCT,CRP,and AGEs were significantly higher in severe dehydration group than in mild dehydration group and moderate dehydration group(P<0.05),and also in moderate dehydration group than in mild dehydration group(P<0.05);the positive rates of PCT and CRP in severe dehydration group(93.33%,93.33%)were significantly higher than those in moderate dehydration group(50.00%,40.00%)and mild dehydration group(20.00%,16.00%);the positive rates of PCT and CRP in moderate dehydration group were significantly higher than those in mild dehydration group(P<0.05).Conclusion PCT,CRP,and AGEs have high specificity and accuracy in evaluating intestinal mucosal damage in children with rotavirus enteritis,which is worthy of clinical application.

关 键 词：轮状病毒肠炎 降钙素原 C-反应蛋白 晚期糖基化终末产物 肠黏膜 损伤 

分 类 号：R725.7[医药卫生—儿科]