肾移植后肺部毛霉菌感染的临床分析  

Clinical analysis of pulmonary mucor infection after kidney transplantation from citizens' death organ donation

作　　者：丁利民[1] 李新长[1] Ding Limin;Li Xinchang(Organ Transplantation Center of Jiangxi Provincial People's Hospital,Nanchang 330006,China)

机构地区：[1]江西省人民医院器官移植科,南昌330006

出　　处：《中华器官移植杂志》2019年第11期687-690,共4页Chinese Journal of Organ Transplantation

基　　金：江西省科技厅重点研发项目基金(20151BBG70069);江西省科技厅重点研发项目基金(20161BBG70121);江西省自然基金项目(20192BAB205021)。

摘　　要：目的探讨肾移植术后肺部毛霉菌感染的发病原因、诊断与治疗。方法回顾性分析2015年1月至2019年6月4例典型肺部毛霉菌感染病例,并结合国内外相关文献进行分析,以期对肾移植后肺部毛霉菌感染的发病时间、临床表现及其诊断、治疗进行总结分析。结果4例引起严重临床症状受者中,3例受者经过及时的对症治疗后好转存活至今,1例因毛霉菌侵犯肺部血管引起血胸导致受者死亡。结论肾移植术后肺部毛霉菌感染进展快,病情凶险,致死率高,及时停用或减量免疫抑制剂以及根据病情单用或联合使用针对毛霉菌的抗菌药物,是挽救受者生命的关键。Objective To explore the causes,diagnosis and treatment of pulmonary mucor infection after kidney transplantation from citizens'death organ donation.Methods A retrospective analysis was performed for the causes,diagnosis and treatment of 4 cases of typical pulmonary mucor infection since the implementation of organ donation and kidney transplantation after death at our hospital from January 2015 to June 2019.Results Among 4 patients with severe clinical symptoms,3 survived after timely symptomatic treatments and 1 patient died due to mucor invasion of pulmonary blood vessels and hemothorax.Conclusions Pulmonary mucor infection is often rapid,aggressive and even fatal after kidney transplantation from citizens'death organ donation.For saving the life of transplant recipients,it is vital to save to withdraw or lower the dose of immunosuppressive agents timely and use antibacterial agents against mucor alone or jointly according to clinical condition.

关 键 词：肾移植 肺部感染 毛霉菌 诊断 治疗 

分 类 号：R699[医药卫生—泌尿科学] R51[医药卫生—外科学]