细菌性肺炎患者血清抗核抗体和抗核抗体谱分析  

An Analysis of Antinuclear Antibody and Antinuclear Antibody Spectrum in Bacterial Pneumonia Patients

作　　者：黎娇 郑凤芝[1] 杨海鹏[1] 伍彬[1] 赵凡 胡守奎[1] LI Jiao;ZHENG Fengzhi;YANG Haipeng;WU Bin;ZHAO Fang;HU Shoukui(Department of Clinical Laboratory,Peking University Shougang Hospital Beijing 100144,China)

机构地区：[1]北京大学首钢医院检验科,北京100144

出　　处：《标记免疫分析与临床》2020年第3期369-371,376,共4页Labeled Immunoassays and Clinical Medicine

基　　金：北京大学首钢医院青年基金(编号:SGYYQ201808)。

摘　　要：目的通过北京大学首钢医院呼吸科住院的细菌性肺炎患者的抗核抗体和抗核抗体谱资料分析,探讨细菌性肺炎患者抗核抗体及抗核抗体谱检测的临床价值。方法选取北京大学首钢医院呼吸科2018年6月至2018年12月间收治的360例细菌性肺炎患者为研究对象,采用间接免疫荧光法检测患者血清抗核抗体、免疫印迹法检测血清抗核抗体谱。结果360例细菌性肺炎患者抗核抗体阳性121例,占33.61%,阳性患者中确诊为自身免疫性疾病的有9例,占7.44%,由于患者不配合检查,疑似自身免疫性疾病的患者7例,占5.78%;抗核抗体阳性的患者中,抗核抗体谱阳性患者41例,9例自身免疫病患者中,8例为抗核抗体谱阳性,1例抗核抗体谱阴性。结论呼吸科住院的细菌性肺炎患者应进行抗核抗体和抗核抗体谱的筛查,以预防自身免疫性疾病的漏诊。Objective By analyzing the antinuclear antibody and antinuclear antibody spectrum of bacterial pneumonia patients in respiratory department of Peking University Shougang Hospital,to investigate the clinical value of detecting the antinuclear antibody and antinuclear antibody spectra among bacterial pneumonia patients.Methods The research objects were 360 inpatients with bacterial pneumonia in the respiratory department of Peking University Shougang Hospital from June,2018 to December,2018.The indirect immunofluorescence method was used to detect the antinuclear antibodies with the serum of the patients.Western blotting was used to detect the serum antinuclear antibody spectrum.Results There were 121 positive antinuclear antibody in 360 patients with bacterial pneumonia,accounted for 33.61%,and 9 positive patients were diagnosed as autoimmune disease,accounted for 7.44%.Because the patient didn′t cooperate with the examination,7 patients were considered as suspected autoimmune diseases,accounted for 5.78%.In patients with positive antinuclear antibody,there were 41 patients with positive antinuclear antibody spectrum.In 9 patients with autoimmune disease,8 cases were positive and 1 cases were negative for antinuclear antibody spectrum.Conclusion Patients with bacterial pneumonia hospitalized in respiratory department should be screened for antinuclear antibody and antinuclear antibody spectrum to prevent the missing diagnosis of autoimmune diseases.

关 键 词：抗核抗体 细菌性肺炎 自身免疫性疾病 早期诊断 

分 类 号：R593.2[医药卫生—内科学]