淫羊藿苷治疗骨不连的分子机制  

Molecular mechanism of icariin in the treatment of bone nonunion

作　　者：余绍涌 章晓云[2] 陈跃平[2] 刘建航 Yu Shaoyong;Zhang Xiaoyun;Chen Yueping;Liu Jianhang(Master Hall of Traditional Chinese Medicine,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,Guangxi Zhuang Autonomous Region,China;Department of Orthopedic Trauma and Hand Surgery,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,Guangxi Zhuang Autonomous Region,China;Beihai Traditional Chinese Medicine Hospital(Beihai Hospital Affiliated to Guangxi University of Chinese Medicine),Beihai 536000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学附属瑞康医院国医大师馆,广西壮族自治区南宁市530011 [2]广西中医药大学附属瑞康医院创伤骨科与手外科,广西壮族自治区南宁市530011 [3]北海市中医医院(广西中医药大学附属北海医院),广西壮族自治区北海市536000

出　　处：《中国组织工程研究》2020年第26期4218-4223,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81760796,81960803),项目负责人:陈跃平;广西中医药管理局项目(GZZC2019096),项目负责人:章晓云;广西卫生健康委员会项目(Z20190345),项目负责人:章晓云;广西中青年教师基础能力提升项目(2019KY0352),项目负责人:章晓云;广西中医药大学自然科学基金课题(2019QN027),项目负责人:章晓云;广西中医药大学一流学科建设开放课题(2019XK029),项目负责人:章晓云。

摘　　要：背景:骨不连是骨科临床上常见的并发症,严重影响患者的身心健康和生活质量。近年来大量的研究发现淫羊藿苷在促进骨折愈合和治疗骨缺损方面有着显著作用;骨不连和骨折愈合是对立共存的,有关骨折愈合机制的研究实际上就是治疗骨不连的研究。目的:综述淫羊藿苷在骨不连治疗过程中的分子机制研究进展。方法:第一作者应用计算机以"icariin,bone nonunion,bone marrow mesenchymal stem cells,periosteal cell,osteoblasts,osteoclast"及"淫羊藿苷、骨不连、骨髓间充质干细胞、骨膜细胞、成骨细胞、破骨细胞"作为主题词检索Pub Med、中国知网、万方、维普数据库,共检索到542篇文献,按入选标准及排除标准进行筛选,最终纳入44篇文献。结果与结论:淫羊藿苷通过促进骨髓间充质干细胞和骨膜细胞增殖及向成骨细胞分化、促进成骨细胞增殖与成熟、抑制破骨细胞的破骨作用,有效促进骨折愈合和治疗骨不连。目前绝大部分研究仍处于基础实验阶段,尚需要大量临床研究,对于相关蛋白及基因方面也有待于进一步研究,希望为骨不连的中药治疗提供新思路。BACKGROUND:Nonunion is a common clinical complication in orthopedics,which seriously impacts the physical and mental health and quality of life of patients.In recent years,a large number of studies have found that icariin plays a significant role in promoting fracture healing and treating bone defects.Bone nonunion and fracture healing coexist,and the research on the mechanism of fracture healing actually focuses on the treatment of bone nonunion.OBJECTIVE:To review the research progress in the molecular mechanism of icariin in the treatment of bone nonunion.METHODS:The first author used"icariin,bone nonunion,bone marrow mesenchymal stem cells,periosteal cell,osteoblasts,osteoclast"askey words in English and Chinese to search Pub Med,CNKI,Wan Fang and VIP databases.A total of 542 articles were retrieved and screened manually according to the selection criteria and exclusion criteria.Finally,44 articles were included for result analysis.RESULTS AND CONCLUSION:Icariin can effectively promote fracture healing and treat bone nonunion by promoting the proliferation and differentiation of bone marrow mesenchymal stem cells and periosteal cells,promoting the proliferation and maturation of osteoblasts and inhibiting the osteoclast effect of osteoclasts.However,most of the experiments are still in the basic experimental research,and there is still a need for a large number of clinical studies as well as studies on related proteins and genes,to provide a new idea for the clinical use of Chinese herbs in the treatment of bone nonunion.

关 键 词：淫羊藿苷 骨不连 骨折不愈合 骨缺损 骨髓间充质干细胞 骨膜细胞 成骨细胞 破骨细胞 

分 类 号：R459.9[医药卫生—治疗学] R394.2[医药卫生—临床医学]