骨质疏松症慢性疼痛机制的研究进展  

Research Progress in Chronic Pain Mechanism of Osteoporosis

作　　者：陈元川[1,2] 庞坚[1,2] 詹红生[1,2] CHEN Yuanchuan;PANG Jian;ZHAN Hongsheng(Shi′s Center of Orthopedics and Traumatology,Shuguang Hospital Affiliated to Shanghai University of TCM,Shanghai 201203,China;Institute of Traumatology&Orthopedics,Shanghai Academy of TCM,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院石氏伤科医学中心,上海201203 [2]上海市中医药研究院骨伤科研究所,上海201203

出　　处：《医学综述》2020年第7期1249-1253,1258,共6页Medical Recapitulate

基　　金：国家自然科学基金(81674003);上海市重中之重临床医学中心和重点学科建设计划(2017ZZ02024);上海市进一步加快中医药事业发展三年行动计划(2018年-2020年)项目(ZY〔2018-2020〕-CCCX-2003-05);第六批全国老中医药专家学术经验继承工作的通知(国中医药人教发〔2017〕29号)。

摘　　要：骨质疏松症是中老年常见的退行性疾病之一,其最常见的临床症状为疼痛,尤其是腰背部疼痛,目前骨质疏松症慢性疼痛的发生机制仍未阐明。近年来,随着对骨质疏松症慢性疼痛发生发展机制研究的不断深入,发现其与破骨细胞活性、中枢敏化、脊柱畸形、情绪状态等因素关系密切。结合骨质疏松症和慢性疼痛的发病机制探索骨质疏松症慢性疼痛的机制对于寻找有效缓解骨质疏松症患者疼痛症状的治疗方法具有积极的指导意义。此外,结合生理与心理因素对骨质疏松症慢性疼痛进行干预,将有助于骨质疏松症慢性疼痛的治疗。Osteoporosis is one of the most common degenerative diseases in the middle-aged and the elderly.The most common clinical symptoms are pain,especially the back pain.At present,the mechanism of chronic pain in osteoporosis is still unclear.In recent years,with the deepening of the research on the pathogenesis and development mechanism,it is found that it is closely related to osteoclast activity,central sensitization,spinal deformity,emotional state and other factors.Combining the pathogenesis of osteoporosis and chronic pain to explore the mechanism of chronic pain in osteoporosis has a positive guiding significance for finding effective treatment methods to alleviate the pain symptoms of the patients.In addition,the intervention combining physiological and psychological factors will be helpful to the treatment.

关 键 词：骨质疏松症 慢性疼痛 疼痛机制 

分 类 号：R681[医药卫生—骨科学] R441.1[医药卫生—外科学]