干扰素联合炎琥宁治疗小儿手足口病的临床效果评价  

Evaluation of Clinical Effect of Interferon Combined With Andrographine in the Treatment of Hand Foot Mouth Disease Children

作　　者：冯友银[1] FENG Youyin(Antiseptic Supply Center,The First People's Hospital of Jingzhou,Jingzhou Hubei 434000,China)

机构地区：[1]湖北省荆州市第一人民医院消毒供应中心,湖北荆州434000

出　　处：《中国继续医学教育》2020年第10期134-137,共4页China Continuing Medical Education

摘　　要：目的 探究干扰素联合炎琥宁治疗小儿手足口病的效果观察.方法 选取2016年4月—2019年3月医院收治的手足口病患儿104例,依随机数字表分为参照组和干预组,各52例.参照组患儿应用干扰素治疗,干预组患儿加用炎琥宁治疗.观察两组患儿的治疗效果、临床症状消退时间、黏附分子表达量和心肌酶水平.结果 干预组患儿治疗总有效率为90.38%,明显高于参照组患儿的75%;干预组患儿发热、口腔溃疡和手足皮疹的消退时间均明显短于参照组患儿(P<0.05);两组患儿治疗后的CD44、ICAM-1、VCAM-1、CK、LDH和CK-MB水平均明显低于治疗前水平(P<0.05),且干预组患儿治疗后的CD44、ICAM-1、VCAM-1、CK、LDH和CK-MB水平均明显低于参照组患儿治疗后水平(P<0.05).结论 干扰素联合炎琥宁治疗小儿手足口病的效果显著.Objective To investigate the effect of interferon combined with Yanhuning in the treatment of children with hand,foot and mouth disease.Methods 104 children with hand,foot and mouth disease admitted to our hospital from April 2016 to March 2019 were divided into reference group and intervention group according to random number table,each with 52 cases.In the reference group children were treated with interferon,and in the intervention group children were treated with andrographine.To observe the therapeutic effect,clinical symptom remission time,adhesion molecular expression and cardiac enzyme level of two groups of children.Results The total effective rate of treatment was 90.38%in the intervention group,which was significantly higher than 75%in the reference group.The regression time of fever,oral ulcer and hand and foot rash in the intervention group was shorter than that of the reference group(P<0.05).The average levels of CD44,ICAM-1,VCAM-1,CK,LDH and CKMB were significantly lower than the pre-treatment levels(P<0.05).The average levels of CD44,ICAM-1,VCAM-1,CK,LDH,and CK-MB after treatment were significantly lower than those after treatment in the reference group(P<0.05).Conclusion Interferon combined with andrographine is effective in the treatment of hand,foot and mouth disease in children.

关 键 词：小儿 手足口病 干扰素 炎琥宁 传染性较强 增强杀灭病毒 

分 类 号：R246[医药卫生—针灸推拿学]