培哚普利不同剂型治疗轻中度高血压的疗效研究  

Efficacy of Different Dosage Forms of Perindopril in the Treatment of Mild to Moderate Hypertension

作　　者：周玲莉 ZHOU Lingli(Department of Pharmacy,Maojian District People’s Hospital of Shiyan,Shiyan Hubei 442012,China)

机构地区：[1]湖北省十堰市茅箭区人民医院药剂科,湖北十堰442012

出　　处：《中国继续医学教育》2020年第10期144-146,共3页China Continuing Medical Education

摘　　要：目的 分析培哚普利精氨酸盐与培哚普利叔丁胺盐两种剂型治疗原发性轻中度高血压患者的疗效.方法 选择医院2016年1月—2019年3月收治的102例原发性轻中度高血压患者纳入本次研究,分为常规组与试验组,其中对常规组患者采取培哚普利叔丁胺盐进行治疗,对试验组患者采取培哚普利精氨酸盐进行治疗,对比两组的临床疗效.结果 试验组(86.27%、84.31%)与常规组(86.27%、82.35%)的治疗有效率无明显差异,P>0.05;试验组治疗8周与12周的血压控制率分别为37.25%、35.29%,常规组分别为35.29%、33.33%,P>0.05;试验组与常规组的不良事件发生率分别为19.61%、17.65%,P>0.05.结论 对原发性轻中度高血压患者采取培哚普利精氨酸盐与培哚普利叔丁胺盐两种剂型进行治疗的临床疗效相当.Objective To analyze without perindopril split and without perindopril arginine salt salt split tert-butylamine two dosage forms the curative effect of treatment of patients with mild-to-moderate hypertension.Methods From January 2016 to March 2019 treated 102 cases of patients with mild-to-moderate hypertension in this study,divided into normal group and experimental group,including the conventional group patients to take without perindopril split tert-butylamine salt treatment,the experimental group patients to take without perindopril split arginine salt treatment,compared two groups of clinical curative effect.Results The experimental group(86.27%,84.31%)and normal group(86.27%,82.35%)no difference between the treatment efficiency,P>0.05;Experimental treatment for 8 weeks and 12 weeks of blood pressure control rates were 37.25%,35.29%,conventional group were 35.29%,35.29%,P>0.05;The experimental group and routine group,the incidence of adverse events are 19.61%,19.61%respectively,P>0.05).Conclusion In patients with primary mildto-moderate hypertension without perindopril split and without perindopril arginine salt split tert-butylamine two formulations for treatment of clinical curative effect,is worth popularizing practice.

关 键 词：原发性轻中度高血压 培哚普利精氨酸盐 培哚普利叔丁胺盐 高血压 不良事件 血压控制率 

分 类 号：R544[医药卫生—心血管疾病]