2-(2,2-二氟乙氧基)-6-三氟甲基苯磺酰氯的合成新路线  

A New Synthetic Route of 2-(2,2-Difluoro-ethoxy)-6-trifluoromethyl-benzenesulfonyl Chloride

作　　者：黄成美 徐海鹏[1] 徐小雨 王宝林[1] Huang Chengmei;Xu Haipeng;Xu Xiaoyu;Wang Baolin(Jiangsu Yangnong Chemical Co.,Ltd.,Yangzhou 225009,China)

机构地区：[1]江苏扬农化工股份有限公司,江苏扬州225009

出　　处：《广东化工》2020年第6期15-16,共2页Guangdong Chemical Industry

摘　　要：以邻溴三氟甲苯为原料,经混酸硝化、溴化、硝基还原、重氮化脱氨基、格氏交换甲硫基化、乌尔曼醚化、氯气氧化等步骤合成2-(2,2-二氟乙氧基)-6-三氟甲基苯磺酰氯。该路线反应条件避免了丁基锂的使用,使其工业化生产更加安全、经济。2-(2,2-Difluoro-ethoxy)-6-trifluoromethyl-benzenesulfonyl chloride was synthe-sized from 2-bromo-trifluoromethyl-benzene via a series of transformations including nitrification, bromination, reduction, deamination by diazotization, preparation of methyl sulfide by Grignard exchange, Ullman etherification and sulfonyl chloride synthesis. Avoiding the use of n-butyllithium makes this route more secure and economic than other ones.

关 键 词：2-(2 2-二氟乙氧基)-6-三氟甲基苯磺酰氯 丁基锂 合成 

分 类 号：TQ[化学工程]