(+)-5-氯-2,3-二氢-2-羟基-l-氧代-1H-茚-2-羧酸甲酯合成  

Synthesis of 5-chloro-2,3-dihydro-2-hydroxy-1-oxy-1h-indene-2-carboxylic Acid Methyl Ester

作　　者：徐海鹏[1] 黄成美 刘其成 Xu Haipeng;Huang Chengmei;Liu Qicheng(Jiangsu Yangnong Chemical Co.,Ltd.,Yangzhou 225009,China)

机构地区：[1]江苏扬农化工股份公司,江苏扬州225009

出　　处：《广东化工》2020年第6期61-62,49,共3页Guangdong Chemical Industry

摘　　要：采用以4-氯苯乙酰氯为起始原料,合成得到手性5-氯-2,3-二氢-2-羟基-1-氧-1H-茚-2-羧酸甲酯。实验重点研究了手性中间体5-氯-2,3-二氢-2-羟基-l-氧代-1 H-茚-2-羧酸甲酯不对称合成过程中氧化剂、催化剂、溶剂、温度等工艺条件对于ee值的影响,最终筛选出了最优的反应条件,收率达到64.15%,ee值达到92%。The chiral 5-chloro-2,3-dihydro-2-hydroxy-1-oxy-1 h-indene-2-carboxylic acid methyl ester was synthesized from 4-chlorophenylacetyl chloride. In the asymmetric synthesis of 5-chloro-2,3-dihydro-2-hydroxy-l-oxo-1 h-indene-2-carboxylic acid methyl ester, the effects of oxidant, catalyst, solvent, temperature and other technological conditions on EE value were studied. The optimal reaction conditions were selected, the yield reached 64.15 %, ee value reached 92 %.

关 键 词：5-氯-2 3二氢-2-羟基-l-氧代-1H-茚-2-羧酸甲酯 不对称合成 催化剂 

分 类 号：TQ[化学工程]