电化学方法合成DL-高半胱氨酸硫内酯盐酸盐  

Electrochemical Synthesis of DL-homocysteinethiolactone Hydrochloride

作　　者：何文秀 周以鸿 胡惠新 骆建轻 程龙进 赖立冬 胡华南 He Wenxiu;Zhou Yihong;Hu Huixin;Luo Jianqing;Cheng Longjin;Lai Lidong;Hu Hua’nan(Jiujiang Zhongxing,Jiujiang 332500;School of Chemical and Environmental Engineering,Jiujiang University,Jiujiang 320025,China)

机构地区：[1]九江中星医药化工有限公司,江西九江332500 [2]九江学院化学与环境工程学院,江西九江320025

出　　处：《广东化工》2020年第4期83-84,共2页Guangdong Chemical Industry

摘　　要：以DL-蛋氨酸为原料,经过浓硫酸和氢溴酸在一定温度和时间催化脱甲基氧化偶联得到DL-高胱氨酸粗品,晶状粗品通过电化学还原法合成得到DL-高半胱氨酸硫内酯盐酸盐。本文对DL-高半胱氨酸硫内酯盐酸盐合成工艺进行了改进,总收率为达到36%~42%,含量99.5%~101.5%。Using DL-Methionine as raw material, the crude product of DL-homocystine was obtained during demethylation catalyzed by concentrated sulfuric acid and hydrohalic acid at a certain temperature and time, DL-homocysteinethiolactone hydrochloride was synthesized by electrochemical reduction of crude DL-homocystine. In this paper, the synthesis process of DL-homocysteinethiolactone hydrochloride was improved. The total yield was 36 %~42 %, and the content was 99.5 %~101.5 %.

关 键 词：DL-蛋氨酸 DL-高胱氨酸 DL-高半胱氨酸硫内酯盐酸盐 电化学还原 

分 类 号：TQ[化学工程]