An Intramolecular Charge Transfer and Aggregation Induced Emission Enhancement Fluorescent Probe Based on 2-Phenyl-1,2,3-triazole for Highly Selective and Sensitive Detection of Homocysteine and Its Application in Living Cells  

作　　者：Yicheng Chu Zhengfeng Xie Daijiao Zhuang Yongshuang Yue Yuhua Yue Wei Shi Shun Feng 

机构地区：[1]Oil&Gas Field Applied Chemistry Key Laboratory of Sichuan Province,College of Chemistry and Chemical Engineering,Southwest Petroleum University,8 Xindu Road,Xindu,Chengdu,Sichuan 610500,China [2]School of Life Science and Engineering,Southwest Jiaotong University,Chengdu,Sichuan 610031,China

出　　处：《Chinese Journal of Chemistry》2019年第12期1216-1222,共7页中国化学（英文版）

基　　金：The author is grateful to SWPU's Youth Science and Technology Innovation Team(No.2017CXTD05)。

摘　　要：Summary of main observation and con elusion In this work,a new simple and readily synthesized turn-on probe 2-(4-anthracene-9-yl-phenyl)-2H-[l,2,3]triazole-4-carbaldehyde(APTC)was legitimately designed towards homocysteine(Hcy).Moreover,APTC has excellent optical properties such as intramolecular charge transfer(ICT)and aggregation induced emission enhancement(AIEE)characteristics,indicating its extensive application potentiality.What's more,APTC displayed rapid,high selectivity and specificity towards homocysteine over cysteine/glutathione.The detection limit of APTC for Hcy was as low as 2.198×10^-8 mol·L^-1,and the response time was only 5 min.APTC has been successfully applied to detect Hcy in silica gel plates and living cells,which indicates that APTC has good stability and biocompatibility as a selective probe for Hcy.Finally,the mechanism was studied using 1H NMR titration experiments and mass spectrometry.

关 键 词：SPECIFICITY Probe HIGHLY 

分 类 号：R54[医药卫生—心血管疾病]