能量代谢在2型糖尿病神经炎症中的作用机制  

Mechanism of Energy Metabolism in Neuroinflammation of Type 2 Diabetes Mellitus

作　　者：宋晓英 唐俊鹏 魏娟英 邹伟[1] SONG Xiaoying;TANG Junpeng;WEI Juanying;ZOU Wei(Department of Neurology,Nanhua Hospital Affiliated to University of South China,Hengyang 421002,China)

机构地区：[1]南华大学附属南华医院神经内科,湖南衡阳421002

出　　处：《医学综述》2020年第6期1177-1182,共6页Medical Recapitulate

基　　金：湖南省研究生科研创新项目(CX20190775)。

摘　　要：能量代谢对维持人体健康具有重要作用,大脑对能量供应变化非常敏感,机体能量代谢失衡会导致疾病。2型糖尿病是一种慢性低度炎症,炎症作为胰岛素抵抗驱动因素参与糖尿病的发生发展。2型糖尿病神经炎症是糖尿病神经系统病变的主要病理特征,影响糖尿病神经系统并发症的进展。能量代谢途径的中间产物、终产物及代谢酶参与炎症反应调控,可能与小胶质细胞活化有关,通过分析能量代谢与神经炎症之间的关系,可为糖尿病脑病的治疗提供新的方向。Energy metabolism plays an important role in maintaining human health.The brain is very sensitive to the change of energy supply.The imbalance of energy metabolism will lead to diseases.Type 2 diabetes mellitus is a kind of chronic low-grade inflammation.Inflammation,as a driving factor of insulin resistance,participates in the development of diabetes.Neuroinflammation in type 2 diabetes mellitus is the main pathological feature of diabetic neuropathy,affecting its development.The intermediates,end products and metabolic enzymes of energy metabolism pathway are involved in the regulation of inflammatory response,which may be related to the activation of microglia.By analyzing the relationship between energy metabolism and neuroinflammation,it can provide a new direction for the treatment of diabetic encephalopathy.

关 键 词：2型糖尿病 能量代谢 神经炎症 

分 类 号：R587.1[医药卫生—内分泌] R339.6[医药卫生—内科学]