疏肝清热方对桥本甲状腺炎患者甲状腺功能及外周血淋巴细胞比例的影响  

Effects of Shugan Qingre Formula on Thyroid Function and Peripheral Blood Lymphocyte Ratio of Patients with Hashimoto Thyroiditis

作　　者：刘小庆[1] 耿中利[1] 张爽 LIU Xiaoqing;GENG Zhongli;ZHANG Shuang(The Second Department of General Surgery,the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University,Urumqi 830000,China;Department of Critical Care Medicine,the Fourth People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830017,China)

机构地区：[1]新疆医科大学附属中医医院普外二科,乌鲁木齐830000 [2]新疆维吾尔自治区第四人民医院重症医学科,乌鲁木齐830017

出　　处：《世界中医药》2020年第6期874-877,共4页World Chinese Medicine

基　　金：新疆维吾尔自治区自然科学基金计划项目(2017D01C165)。

摘　　要：目的:探讨疏肝清热方对桥本甲状腺炎(HT)患者甲状腺功能及外周血淋巴细胞比例的影响。方法:选取2014年11月至2016年11月新疆医科大学附属中医医院收治的HT患者94例进行回顾性分析。按照治疗方法不同分为对照组和观察组,每组47例。对照组用左甲状腺素钠片治疗,观察组在对照组的基础上联合疏肝清热方治疗,2组均连续治疗12周。比较2组治疗后临床疗效;统计治疗前后2组临床症状积分、甲状腺功能指标及外周血淋巴细胞比例。结果:治疗后,观察组治疗有效率为93.62%,显著高于对照组的74.46%(P<0.05);与治疗前比较,治疗后2组患者颈前瘿肿或压迫感、失眠、多汗、口干、便秘等中医证候积分均明显下降,且观察组显著低于对照组,差异有统计学意义(P<0.05);治疗前后2组患者FT 3、FT 4水平及组间比较,差异无统计学意义(P>0.05),治疗后2组TSH水平均较治疗前显著降低,且观察组显著低于对照组,差异有统计学意义(P<0.05);治疗前后对照组TRAb、TPOAb、TGAb水平及观察组TRAb水平差异无统计学意义(P>0.05),治疗后,观察组TPOAb、TGAb水平均显著下降,且低于对照组,差异无统计学意义(P<0.05);治疗后,观察组CCR5%、CD30%及CCR5%/CD30%比值均降低(P<0.05);治疗后观察组与对照组以上比值差异无统计学意义(P>0.05)。结论:疏肝清热方治疗HT可缓解患者相关临床症状,促进甲状腺激素与抗体水平恢复正常,改善患者甲状腺功能,但未能改善外周血淋巴细胞比例。Objective:To explore effects of Shugan Qingre Formula on thyroid function and peripheral blood lymphocyte ratio of patients with Hashimoto Thyroiditis(HT).Methods:Retrospective study was performed on 94 patients with HT,admitted to the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University from November 2014 to November 2016,who were divided into a control group and an observation group by different treatment methods.Each group had 47 cases.The control group were treated with levothyroxine sodium Tablets,and observation group were treated based on the treatment of control group with combined Shugan Qingre Formula.Both 2 groups had been treated for 12 weeks continuously.Clinical effects of 2 groups after treatment were compared;clinical symptom scores,thyroid function index and peripheral blood lymphocyte ratios of them were counted before and after treatment.Results:The total effective rate of observation group was 93.62%after treatment,which was higher than that 74.46%of the control group(P<0.05).Compared with those before treatment,TCM clinical symptom scores of 2 groups decreased evidently after treatment,such as anterior swelling or oppression of neck,insomnia,sweating,dry mouth and constipation etc.,and the scores of observation group was lower obviously than those of the control group(P<0.05).There was no obvious difference on the levels of FT 3,FT 4 between 2 groups(P>0.05);levels of TSH of 2 groups decreased evidently after treatment,and the level of observation group was lower than that of control group(P<0.05);The levels of TRAb,TPOAb and TGAb in the control group and the level of TRAb in the observation group had no significant change before and after treatment(P>0.05),and the levels of TPOAb and TGAb in the observation group decreased significantly after treatment and were lower than those in the control group(P<0.05);CCR5%,CD30%,and CCR5%/CD30%ratios of the observation group were decreased(P<0.05)after treatment,there were no significant difference in the above ratios betw

关 键 词：桥本甲状腺炎 疏肝清热方 甲状腺功能 淋巴细胞比例 

分 类 号：R289.5[医药卫生—方剂学] R582[医药卫生—中药学]