表面等离子共振技术研究进展及应用  

Research progress and application of surface plasmon resonance technology

作　　者：王永智 叶华跃 聂利芳 吴宏斌 邱文娜 方朝东 雷高新 曾玮乔 WANG Yongzhi;YE Huayue;NIE Lifang;WU Hongbin;QIU Wenna;FANG Chaodong;LEI Gaoxin;ZENG Weiqiao(Vaccine Engineering Center of Taizhou Pharmaceutical High-tech Industrial Park Jiangsu,Taizhou 225300,China;Jiangsu Huatai Vaccine Engineering Technology Research Co.,Ltd.,Jiangsu,Taizhou 225300,China;Jiangsu Union Pharmaceutical Co.,Ltd.,Jiangsu,Taizhou 225300,China)

机构地区：[1]泰州医药高新技术产业园区疫苗工程中心,江苏泰州225300 [2]江苏华泰疫苗工程技术研究有限公司,江苏泰州225300 [3]江苏大同盟制药有限公司,江苏泰州225300

出　　处：《中国医药科学》2020年第6期17-21,共5页China Medicine And Pharmacy

基　　金：江苏省泰州市科技支撑计划(社会发展)项目(TS201834)。

摘　　要：表面等离子体共振(SPR)技术是自20世纪70年代逐步发展起来的一种光学生化检测技术.经过几十年的发展,因该技术具有样品免标记、需求量小、检测快速、灵敏度高、特异性强、选择性高等优势,已逐步发展成为分子生物学、环境污染物分析、食品安全检测、药物研发等领域常用的分析工具.本文系统综述了SPR技术发展的历史及在各个领域的应用情况,并展望了SPR技术未来发展的趋势.Surface plasmon resonance(SPR)technology is a photochemical detection technology that has been gradually developed since the 1970s.After decades of development,the technology has the advantages of labelfree samples,small demand,fast detection,high sensitivity,strong specificity,and high selectivity.It has also gradually developed into a commonly used analytical tool in the fields of molecular biology,environmental pollutant analysis,food safety testing and drug development.This article systematically summarizes the history of SPR technology development and its application in various fields,and looks forward to the future development trend of SPR technology.

关 键 词：表面等离子共振(SPR) 生物分子相互作用 生物传感器 环境内分泌干扰物 药物筛选 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]