双组分系统RaxH/RaxR与RavA/RavR的共进化关系  

Co-evolution Analysis of RaxH/RaxR and RavA/RavR Two-Component Signal Transduction Systems

作　　者：李婷[1] 林玉暖 林茂娟 牛晓磊[1] 李春霞[1] 陈银华[1] 陶均[1] Li Ting;Lin Yunuan;Lin Maojuan;Niu Xiaolei;Li Chunxia;Chen Yinhua;Tao Jun(Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University, Haikou 570228, China)

机构地区：[1]海南大学海南省热带生物资源可持续利用重点实验室/热带作物学院,海南海口570228

出　　处：《海南大学学报（自然科学版）》2020年第1期46-51,共6页Natural Science Journal of Hainan University

基　　金：国家自然科学基金(31660507);海南省研究生创新科研课题项目(Hys2018-01);海南大学科研启动基金(kyqd1546)。

摘　　要：本研究对细菌中的两个双组分系统(RaxH/RaxR与RavA/RavR)之间及其自身两个蛋白之间是否具有共进化特征进行了分析,发现其存在高度的共进化关系,预示它们之间在信号传导中可能处于某一传导途径的不同节点.通过遗传分析发现,RaxH/RaxR在转录水平上调控ravA/ravR的表达,应位于RavA/RavR信号传递的上游.由于RaxH/RaxR可能感应和传导群体信号,而RavA/RavR又调控细胞第二信使c-di-GMP的代谢,所以此双组分级联系统可能在细菌群体行为中扮演重要的角色.In the report,the co-evolution analysis of two TCSTSs:RaxH/RaxR and RavA/RavR,and the two proteins of themselves,were performed.The results indicated that there are high co-evolution relationship between them,which suggest that the two TCSTSs may belong to the same signal pathway.The further analysis showed that RaxH/RaxR might locate at the upstream of RavA/RavR in the virulence-related signaling pathways.Because RaxH/RaxR not only can sense and conduct population signal,but also regulate the metabolism of c-di-GMP,the signaling cascade of RaxH/RaxR and RavA/RavR might play important roles in quorum sensing of bacteria.

关 键 词：双组分系统 共进化 RaxH/RaxR RavA/RavR 转录调控 

分 类 号：S718.83[农业科学—林学] Q349.53[生物学—遗传学]