离子通道类镇痛药物作用机制及研究进展  

Mechanisms of Ion Channel-Targeting Analgesic Drugs and Related Research Progress

作　　者：于瑞河 戚微岩[1] 刘晨[1] 高新梅 徐寒梅[1] YU Ruihe;QI Weiyan;LIU Chen;GAO Xinmei;XU Hanmei(The Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu Province,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学江苏省合成多肽药物发现与评价研究工程中心,江苏南京211198

出　　处：《药学进展》2020年第1期56-65,共10页Progress in Pharmaceutical Sciences

摘　　要：疼痛普遍存在于人类与多种动物中,其机制较为复杂,并影响广泛。目前的疗法通常无法达到预期的疗效和耐受性,因此疼痛的有效治疗仍然是一个挑战。对离子通道信号转导的调节,已经展现出良好的镇痛优势。然而,人类基因组中存在的215个离子通道,其中仅85个离子通道与疼痛有明显联系,且仅少数可用于疼痛的治疗。综述目前在研的离子通道类药物作用机制及最新研究进展。Humans and most animals can have the feeling of pain which is caused by complex mechanisms and has a wide range of influences.Current therapeutics often fail to achieve the desired efficacy and tolerability,leaving the effective treatment of pain remains a challenge.Presently,modulation of ion channel signaling has shown its analgesic advantage.However,among the 215 ion channels in human genome,only 85 of them are strongly associated with pain,and only a few are useful for pain treatment.Here we focused on the latest advances in research of mechanisms of ion channel-targeting analgesic drugs.

关 键 词：镇痛药物 离子通道 钙离子 钠离子 

分 类 号：R971[医药卫生—药品]