探讨拉贝洛尔联合硫酸镁治疗妊娠期高血压疾病的临床效果  

Discussion on clinical effect of labetalol combined with magnesium sulfate in treating hypertensive disorder complicating pregnancy

作　　者：杨立燕 YANG Li-yan(Yanggu County People’s Hospital,Liaocheng 252300,China)

机构地区：[1]聊城市阳谷县人民医院,252300

出　　处：《中国实用医药》2020年第8期4-7,共4页China Practical Medicine

摘　　要：目的探讨拉贝洛尔联合硫酸镁治疗妊娠期高血压疾病的临床效果。方法100例妊娠期高血压疾病患者,按随机数字表法分为A组和B组,每组50例。A组采用拉贝洛尔联合硫酸镁治疗,B组采用硝苯地平联合硫酸镁治疗。比较两组临床疗效、血压、血浆脑钠肽(BNP)、24 h尿蛋白定量、妊娠结局和不良反应发生情况。结果A组治疗总有效率为92.00%,高于B组的74.00%,差异有统计学意义(P<0.05)。治疗14 d后,A组舒张压、收缩压、BNP、24 h尿蛋白定量水平分别为(74.65±4.95)mm Hg(1 mm Hg=0.133 kPa)、(129.87±11.96)mm Hg、(223.65±80.65)pg/L、(712.96±115.32)mg/24 h,均低于B组的(94.05±6.87)mm Hg、(146.21±10.24)mm Hg、(324.21±80.42)pg/L、(844.21±142.61)mg/24 h,差异有统计学意义(P<0.05)。A组自然分娩率64.00%高于B组的44.00%,产后感染率4.00%、产后出血率4.00%均低于B组的16.00%、18.00%,差异具有统计学意义(P<0.05)。A组新生儿窒息率、宫内窘迫率、胎盘早剥率分别为2.00%、4.00%、0,均低于B组的14.00%、18.00%、10.00%,差异具有统计学意义(P<0.05)。A组不良反应发生率为6.00%,低于B组的20.00%,差异具有统计学意义(P<0.05)。结论妊娠期高血压疾病患者使用拉贝洛尔联合硫酸镁治疗安全性较高,可有效改善临床症状,降低血压、BNP、24 h尿蛋白定量水平,提高自然分娩率,改善母婴结局。Objective To discuss the clinical effect of labetalol combined with magnesium sulfate in treating hypertensive disorder complicating pregnancy.Methods A total of 100 patients with hypertensive disorder complicating pregnancy were divided into group A and group B by random number table method,with 50 cases in each group.Group A was treated by labetalol combined with magnesium sulfate,and group B was treated by nifedipine combined with magnesium sulfate.The clinical efficacy,blood pressure,brain natriuretic peptide(BNP),24-h urinary protein quantification,pregnancy outcome and occurrence of adverse reactions were compared between the two groups.Results After 14 d of treatment,the total effective rate of treatment was 92.00%in group A,which was higher than 74.00%in group B,and the difference was statistically significant(P<0.05).The diastolic blood pressure,systolic blood pressure,BNP and 24-h urinary protein quantification were(74.65±4.95)mm Hg(1 mm Hg=0.133 kPa),(129.87±11.96)mm Hg,(223.65±80.65)pg/L and(712.96±115.32)mg/24 h respectively in group A,which were lower than(94.05±6.87)mm Hg,(146.21±10.24)mm Hg,(324.21±80.42)pg/L and(844.21±142.61)mg/24 h in group B,and their difference was statistically significant(P<0.05).The spontaneous delivery rate 64.00%in group A was higher than 44.00%in group B,and postpartum infection rate 4.00%and postpartum hemorrhage rate 4.00%were lower than 16.00%and 18.00%in group B.Their difference was statistically significant(P<0.05).The neonatal asphyxia rate,intrauterine distress rate,placental abruption rate were 2.00%,4.00%and 0 respectively in group A,which were lower than 14.00%,18.00%and 10.00%in group B,and their difference was statistically significant(P<0.05).The incidence of adverse reactions was 6.00%in group A,which was lower than 20.00%in group B,and the difference was statistically significant(P<0.05).Conclusion It is safe to use rabeprolol combined with magnesium sulfate in the treatment of hypertensive disorder complicating pregnancy.It can effectively improv

关 键 词：妊娠期高血压疾病 拉贝洛尔 硫酸镁 妊娠结局 脑钠肽 24 h尿蛋白定量 

分 类 号：R714.246[医药卫生—妇产科学]