不同强度抗凝在老年非瓣膜病慢性房颤治疗中的效果  

Effects of different intensity anticoagulation regimens on elderly patients with chronic atrial fibrillation and non-valvular disease

作　　者：史晓甜 杜康彭 SHI Xiaotian;DU Kangpeng(Department of Pharmacy of Tongshan District People’s Hospital,Xuzhou 221000 Jiangsu,China)

机构地区：[1]徐州市铜山区人民医院药剂科,江苏徐州221000

出　　处：《中国民康医学》2020年第4期11-12,15,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨不同强度抗凝在老年非瓣膜病慢性房颤治疗中的效果。方法:选取老年非瓣膜病慢性房颤患者60例为研究对象,按随机数字表法分为观察组与对照组各30例。观察组采用标准强度抗凝治疗,对照组采用低强度抗凝治疗。比较两组治疗前后的D-二聚体水平、各项凝血指标水平、治疗后患者不良事件发生率。结果:治疗后,观察组D-二聚体水平低于对照组,差异有统计学意义(P<0.05);观察组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)短于对照组,差异有统计学意义(P<0.05);两组凝血酶时间(TT)、纤维蛋白原(FIB)比较,差异无统计学意义(P>0.05);观察组血栓栓塞事件发生率低于对照组,差异有统计学意义(P<0.05);两组患者出血率比较,差异无统计学意义(P>0.05)。结论:应用标准强度抗凝治疗老年非瓣膜病慢性房颤患者,可有效改善患者D-二聚体及各项凝血指标水平,显著降低患者血栓栓塞事件发生率,具有较高安全性。Objective:To investigate effects of different intensity anticoagulation regimens on elderly patients with chronic atrial fibrillation and non-valvular disease.Methods:60 elderly patients with chronic atrial fibrillation and non-valvular disease were selected as the research subjects,and were divided into observation group(n=30)and control group(n=30)by using the random number table method.The observation group was treated with standard intensity anticoagulation,while the control group was treated with low intensity anticoagulation.The D-dimer level,various coagulation indexes,and incidence of thromboembolism and bleeding adverse event were compared between the two groups before and after the treatment.Results:After the treatment,the D-dimer level in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The PT and APTT in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in TT and FIB between the two groups(P>0.05).The incidence of thromboembolism in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Further,there was no significant difference in the bleeding rate between the two groups(P>0.05).Conclusions:For the elderly patients with chronic atrial fibrillation and non-valvular disease,the standard intensity anticoagulation can effectively improve the D-dimer level and various coagulation index levels,and significantly reduce the incidences of thromboembolic with high safety.

关 键 词：低强度抗凝 标准强度抗凝 老年非瓣膜病慢性房颤 疗效 

分 类 号：R541.75[医药卫生—心血管疾病]